Studies of serum ceruloplasmin of Hodgkin disease patients with single drug and combination chemotherapy (Hungarian)

I. Toth, I. Bodrogi, E. Dobrentey, S. Eckhardt

Research output: Contribution to journalArticle

Abstract

30 healthy individuals and 42 stage III-IV Hodgkin disease patients proved by histology were tested. The authors tried to find answers to three questions: What kinds of alterations of the serum ceruloplasmin levels of stage III-IV Hodgkin disease patients can be found following single drug (VM 26, Vinblastine, Endoxan) and combination chemotherapy (VM 26 + Natulan + Prednisolone, Vincristine + Natulan + Prednisolone) compared to the values of untreated patients; Whether successful treatment results in a more marked change than those processes progressing despite therapy; Whether correlations can be proved between ceruloplasmin and other biochemical parameters of the disease. Untreated Hodgkin disease patients showed a marked increase in serum ceruloplasmin levels compared to the normal controls. Successful treatment resulting in complete or partial remissions showed decreased or normalized serum ceruloplasmin levels. (During the studies it could be achieved only by combination chemotherapy). At processes progressing despite chemotherapy an increase or no change could be seen. A positive correlation between serum ceruloplasmin levels and erythrocyte sedimentation rate could be found. The determination of serum ceruloplasmin levels to follow the effectivity of the treatment has been proved to be a suitable biochemical parameter.

Original languageEnglish
Pages (from-to)242-249
Number of pages8
JournalMagyar Onkologia
Volume19
Issue number4
Publication statusPublished - 1975

Fingerprint

Ceruloplasmin
Drug Combinations
Combination Drug Therapy
Hodgkin Disease
Serum
Teniposide
Procarbazine
Prednisolone
Vinblastine
Blood Sedimentation
Vincristine
Therapeutics
Cyclophosphamide
Histology
Drug Therapy
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Cancer Research

Cite this

Studies of serum ceruloplasmin of Hodgkin disease patients with single drug and combination chemotherapy (Hungarian). / Toth, I.; Bodrogi, I.; Dobrentey, E.; Eckhardt, S.

In: Magyar Onkologia, Vol. 19, No. 4, 1975, p. 242-249.

Research output: Contribution to journalArticle

@article{d78eb4bef849437194d2e56d4cb823b7,
title = "Studies of serum ceruloplasmin of Hodgkin disease patients with single drug and combination chemotherapy (Hungarian)",
abstract = "30 healthy individuals and 42 stage III-IV Hodgkin disease patients proved by histology were tested. The authors tried to find answers to three questions: What kinds of alterations of the serum ceruloplasmin levels of stage III-IV Hodgkin disease patients can be found following single drug (VM 26, Vinblastine, Endoxan) and combination chemotherapy (VM 26 + Natulan + Prednisolone, Vincristine + Natulan + Prednisolone) compared to the values of untreated patients; Whether successful treatment results in a more marked change than those processes progressing despite therapy; Whether correlations can be proved between ceruloplasmin and other biochemical parameters of the disease. Untreated Hodgkin disease patients showed a marked increase in serum ceruloplasmin levels compared to the normal controls. Successful treatment resulting in complete or partial remissions showed decreased or normalized serum ceruloplasmin levels. (During the studies it could be achieved only by combination chemotherapy). At processes progressing despite chemotherapy an increase or no change could be seen. A positive correlation between serum ceruloplasmin levels and erythrocyte sedimentation rate could be found. The determination of serum ceruloplasmin levels to follow the effectivity of the treatment has been proved to be a suitable biochemical parameter.",
author = "I. Toth and I. Bodrogi and E. Dobrentey and S. Eckhardt",
year = "1975",
language = "English",
volume = "19",
pages = "242--249",
journal = "Magyar Onkologia",
issn = "0025-0244",
publisher = "Akademiai Kiado",
number = "4",

}

TY - JOUR

T1 - Studies of serum ceruloplasmin of Hodgkin disease patients with single drug and combination chemotherapy (Hungarian)

AU - Toth, I.

AU - Bodrogi, I.

AU - Dobrentey, E.

AU - Eckhardt, S.

PY - 1975

Y1 - 1975

N2 - 30 healthy individuals and 42 stage III-IV Hodgkin disease patients proved by histology were tested. The authors tried to find answers to three questions: What kinds of alterations of the serum ceruloplasmin levels of stage III-IV Hodgkin disease patients can be found following single drug (VM 26, Vinblastine, Endoxan) and combination chemotherapy (VM 26 + Natulan + Prednisolone, Vincristine + Natulan + Prednisolone) compared to the values of untreated patients; Whether successful treatment results in a more marked change than those processes progressing despite therapy; Whether correlations can be proved between ceruloplasmin and other biochemical parameters of the disease. Untreated Hodgkin disease patients showed a marked increase in serum ceruloplasmin levels compared to the normal controls. Successful treatment resulting in complete or partial remissions showed decreased or normalized serum ceruloplasmin levels. (During the studies it could be achieved only by combination chemotherapy). At processes progressing despite chemotherapy an increase or no change could be seen. A positive correlation between serum ceruloplasmin levels and erythrocyte sedimentation rate could be found. The determination of serum ceruloplasmin levels to follow the effectivity of the treatment has been proved to be a suitable biochemical parameter.

AB - 30 healthy individuals and 42 stage III-IV Hodgkin disease patients proved by histology were tested. The authors tried to find answers to three questions: What kinds of alterations of the serum ceruloplasmin levels of stage III-IV Hodgkin disease patients can be found following single drug (VM 26, Vinblastine, Endoxan) and combination chemotherapy (VM 26 + Natulan + Prednisolone, Vincristine + Natulan + Prednisolone) compared to the values of untreated patients; Whether successful treatment results in a more marked change than those processes progressing despite therapy; Whether correlations can be proved between ceruloplasmin and other biochemical parameters of the disease. Untreated Hodgkin disease patients showed a marked increase in serum ceruloplasmin levels compared to the normal controls. Successful treatment resulting in complete or partial remissions showed decreased or normalized serum ceruloplasmin levels. (During the studies it could be achieved only by combination chemotherapy). At processes progressing despite chemotherapy an increase or no change could be seen. A positive correlation between serum ceruloplasmin levels and erythrocyte sedimentation rate could be found. The determination of serum ceruloplasmin levels to follow the effectivity of the treatment has been proved to be a suitable biochemical parameter.

UR - http://www.scopus.com/inward/record.url?scp=0016814094&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016814094&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0016814094

VL - 19

SP - 242

EP - 249

JO - Magyar Onkologia

JF - Magyar Onkologia

SN - 0025-0244

IS - 4

ER -