Studies into hormonal imprinting in intact and transformed 3T3 fibroblast cell lines

P. Kovács, Y. Okano, G. Csaba

Research output: Contribution to journalArticle

Abstract

The cells of the NIH 3T3 fibroblast line responded to primary interaction with insulin by a positive imprinting, i.e. by an increased binding capacity for the hormone on re-exposure. Positive imprinting, although to a lesser degree, was also induced by thyrotropin. However, oncogenic transformation by polyoma virus oncogens resulted in decreased imprinting in both the middle-T-antigen (MT3) and small-T-antigen-expressing (N4) cells.

Original languageEnglish
Pages (from-to)721-725
Number of pages5
JournalBioscience Reports
Volume9
Issue number6
DOIs
Publication statusPublished - Dec 1989

Fingerprint

3T3 Cells
Viral Tumor Antigens
Fibroblasts
Cells
Cell Line
Polyomavirus
NIH 3T3 Cells
Thyrotropin
Viruses
Carcinogens
Hormones
Insulin

Keywords

  • fibroblasts
  • hormonal imprinting
  • insulin
  • small or middle T antigen
  • TSH

ASJC Scopus subject areas

  • Cell Biology
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Studies into hormonal imprinting in intact and transformed 3T3 fibroblast cell lines. / Kovács, P.; Okano, Y.; Csaba, G.

In: Bioscience Reports, Vol. 9, No. 6, 12.1989, p. 721-725.

Research output: Contribution to journalArticle

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