Structure of the chicken link protein gene: exons correlate with the protein domains.

I. Kiss, F. Deák, S. Mestrić, H. Delius, J. Soos, K. Dékány, W. S. Argraves, K. J. Sparks, P. F. Goetinck

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Abstract

The structure of the chicken link protein gene has been determined from a series of genomic clones that cover the entire coding region as well as the complete 3'-untranslated region and a small portion of the 5'-untranslated region. The gene is greater than 80 kilobase pairs long and is present in a single copy in the chicken genome. The link protein gene contains at least five exons with four encoding the entire protein. The domain of link protein that has homologies with immunoglobulin-like proteins and the tandemly repeated hyaluronic acid binding domains are each encoded by separate exons. The exon-intron structure indicates that the link protein gene may have arisen by exon duplication and exon shuffling.

Original languageEnglish
Pages (from-to)6399-6403
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume84
Issue number18
DOIs
Publication statusPublished - Sep 1987

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Cite this

Kiss, I., Deák, F., Mestrić, S., Delius, H., Soos, J., Dékány, K., Argraves, W. S., Sparks, K. J., & Goetinck, P. F. (1987). Structure of the chicken link protein gene: exons correlate with the protein domains. Proceedings of the National Academy of Sciences of the United States of America, 84(18), 6399-6403. https://doi.org/10.1073/pnas.84.18.6399