Structure of complement receptor 2 in complex with its C3d ligand

G. Szakonyi, J. M. Guthridge, D. Li, K. Young, V. M. Holers, X. S. Chen

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124 Citations (Scopus)


Complement receptor 2 (CR2/CD21) is an important receptor that amplifies B lymphocyte activation by bridging the innate and adaptive immune systems. CR2 ligands include complement C3d and Epstein-Barr virus glycoprotein 350/220. We describe the x-ray structure of this CR2 domain in complex with C3d at 2.0 angstroms. The structure reveals extensive main chain interactions between C3d and only one short consensus repeat (SCR) of CR2 and substantial SCR side-side packing. These results provide a detailed understanding of receptor-ligand interactions in this protein family and reveal potential target sites for molecular drug design.

Original languageEnglish
Pages (from-to)1725-1728
Number of pages4
Issue number5522
Publication statusPublished - Jun 1 2001


ASJC Scopus subject areas

  • General

Cite this

Szakonyi, G., Guthridge, J. M., Li, D., Young, K., Holers, V. M., & Chen, X. S. (2001). Structure of complement receptor 2 in complex with its C3d ligand. Science, 292(5522), 1725-1728.