A hypophysis adenilát-cikláz aktiváló polipeptid szerkezete, elófordulása és szerepe az élettani múködésekben.

Translated title of the contribution: Structure, localization and physiologic role of pituitary adenylate cyclase activating polypeptide (PACAP)

E. Vincze, K. Köves

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

PACAP was isolated on the basis of its ability to stimulate adenylate cyclase in primary anterior pituitary cell culture from ovine hypothalami by Miyata et al. in 1989. This peptide is structurally related to the secretin family and shows a 67% sequence homology with vasoactive intestinal polypeptide (VIP). The amino acid sequence of PACAP has been highly preserved during the evolution that may be connected with its important physiological role. Similar to other "brain-gut peptides" PACAP is localized not only in the central but in the peripheral nervous system and in non-neural tissues as well. In addition to its hypophysiotropic effects in the hypothalamo-hypophysial system PACAP exerts its effects on water-salt balance, cardiovascular functions, gastrointestinal motility and secretion and also on the regulation of reproductive functions. PACAP has a role in certain neuro-immuno-endocrine processes, in the differentiation of the nervous system, and it has neuroprotective effects in the case of ischaemia and various toxic agents. Locally PACAP takes its effects as an auto- and paracrine hormone, a neurotransmitter or a neuromodulator in different organs. Besides VIP, PACAP plays an important role in the function of the photo-neuro-endocrine system.

Original languageHungarian
Pages (from-to)491-496
Number of pages6
JournalOrvosi Hetilap
Volume142
Issue number10
Publication statusPublished - Mar 11 2001

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Pituitary Adenylate Cyclase-Activating Polypeptide
Vasoactive Intestinal Peptide
Neurotransmitter Agents
Hypothalamo-Hypophyseal System
Peptides
Endocrine System
Gastrointestinal Motility
Secretin
Poisons
Peripheral Nervous System
Neuroprotective Agents
Sequence Homology
Adenylyl Cyclases
Nervous System
Hypothalamus
Amino Acid Sequence
Sheep
Ischemia
Cell Culture Techniques
Salts

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A hypophysis adenilát-cikláz aktiváló polipeptid szerkezete, elófordulása és szerepe az élettani múködésekben. / Vincze, E.; Köves, K.

In: Orvosi Hetilap, Vol. 142, No. 10, 11.03.2001, p. 491-496.

Research output: Contribution to journalArticle

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