Structure elucidation of the antibiotic desertomycin through the use of new two-dimensional NMR techniques

Ad Bax, A. Aszalos, Z. Dinya, K. Sudo

Research output: Contribution to journalArticle

190 Citations (Scopus)

Abstract

The structure of the antibiotic desertomycin has been determined by using modern two-dimensional NMR techniques. Mass spectroscopy indicated a Mr of 1192. All other structural information was obtained from 1H and 13C NMR. 1H-1H double-quantum-filtered COSY and homonuclear Hartmann-Hahn spectroscopy in combination with heteronuclear shift correlation and 1H-detected heteronuclear multiple-bond multiple-quantum coherence were used for obtaining all crucial connectivities required for establishing the structure. Complete 1H and 13C assignments are also presented. The apparent molecular formula of desertomycin was determined as C61H109NO21.

Original languageEnglish
Pages (from-to)8056-8063
Number of pages8
JournalJournal of the American Chemical Society
Volume108
Issue number25
Publication statusPublished - 1986

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Antibiotics
Nuclear magnetic resonance
Spectroscopy
Anti-Bacterial Agents
Mass Spectrometry
Spectrum Analysis
desertomycin
Proton Magnetic Resonance Spectroscopy
Carbon-13 Magnetic Resonance Spectroscopy

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Structure elucidation of the antibiotic desertomycin through the use of new two-dimensional NMR techniques. / Bax, Ad; Aszalos, A.; Dinya, Z.; Sudo, K.

In: Journal of the American Chemical Society, Vol. 108, No. 25, 1986, p. 8056-8063.

Research output: Contribution to journalArticle

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