Structure elucidation of fumagillin-related natural products

Judit Halász, Benjamin Podányi, Lelle Vasvári-Debreczy, Anna Szabó, Félix Hajdú, Zsolt Böcskei, Judit Hegedus-Vajda, Andrea Gyorbíró, István Hermecz

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Abstract

Fumagillin is currently the only means of treatment of microsporidiosis, which is frequent and fatal in AIDS patients. Results relating to NMR and X-ray crystallographic studies of fumagillin and the structure elucidation of three related compounds are reported. In the main impurity of fumagillin there is an exocyclic double bond instead of the spiroepoxide moiety. The solid-state and solution structures of fumagillin were compared with the conformation of fumagillin complexed to aminopeptidase-2. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)10081-10085
Number of pages5
JournalTetrahedron
Volume56
Issue number51
DOIs
Publication statusPublished - Dec 15 2000

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Keywords

  • Amebicidal activity
  • Antiparasitic activity
  • Conformation
  • NMR
  • X-ray diffraction

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Halász, J., Podányi, B., Vasvári-Debreczy, L., Szabó, A., Hajdú, F., Böcskei, Z., Hegedus-Vajda, J., Gyorbíró, A., & Hermecz, I. (2000). Structure elucidation of fumagillin-related natural products. Tetrahedron, 56(51), 10081-10085. https://doi.org/10.1016/S0040-4020(00)00979-0