Structure elucidation and antioxidant activity of (-)-isosilandrin isolated from silybum marianum L.

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19 Citations (Scopus)

Abstract

A regioisomer of the known flavanolignan (-)-silandrin (3a), named (-)-isosilandrin (8a), was isolated from the fruits of a white-flowered variant of Silybum marianum L. populated in Hungary. Its structure was established both by spectroscopic methods and total synthesis, and its absolute configuration was determined by means of circular dichroism. This compound showed stronger inhibitory activity on the superoxide anion (O- 2 ) release by human polymorphonuclear leukocytes (PMNL) than (-)-silybin (1a,b).

Original languageEnglish
Pages (from-to)1668-1677
Number of pages10
JournalChemistry and Biodiversity
Volume1
Issue number11
DOIs
Publication statusPublished - Nov 1 2004

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Molecular Medicine
  • Molecular Biology

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