A szerkezet-alapu gyogyszertervezes modszerei

Translated title of the contribution: Structure-based drug design

Research output: Contribution to journalReview article

1 Citation (Scopus)


Structure-based drug design is not only a fundamental tool in the search of new drugs but also an area of intensive scientific research. The present contribution starts with a critical analysis of the potentiality of the structure based design and then reviews its methods. Protein crystallography, NMR, homology modelling and the use of antibodies are either referenced or briefly described as the methods which are able to provide us with the atomic structure of receptors. The search of lead molecules by data base mining and by generating structures with computers is discussed. Various methods and computer programs for calculating the interaction energy between receptors and ligands are reviewed. Several examples of successful structure base design are cited and some of them are briefly discussed.

Translated title of the contributionStructure-based drug design
Original languageHungarian
Pages (from-to)21-31
Number of pages11
JournalActa pharmaceutica Hungarica
Issue number1
Publication statusPublished - Jan 1 1998

ASJC Scopus subject areas

  • Pharmaceutical Science

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