Structure and specificity of complement receptors

R. B. Sim, V. Malhotra, A. J. Day, A. Erdei

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Fifteen to 16 cell surface proteins which interact with soluble components of the complement system have now been identified. Most of these - CR1, CR2, CR3, "CR4", DAF, HSV-1 c glycoprotein, Gp 45-70, p150,95, cell-surface Factor H, and a 90 kD protein - interact with C3 or C4 and their degradation products. Other receptors for C1q, Factor H, C5a, and the C5b-9 complex have been identified. Receptors for additional complement proteins such as Factor B or its fragments are likely to exist. Complement receptors have a wide tissue distribution and have major roles in (1) controlling the turnover of the complement system, and (2) regulating behaviour and growth of leukocytes.

Original languageEnglish
Pages (from-to)183-190
Number of pages8
JournalImmunology Letters
Volume14
Issue number3
DOIs
Publication statusPublished - 1987

Fingerprint

Complement C2
Complement Membrane Attack Complex
Complement Factor H
Complement Receptors
Complement Factor B
Human Herpesvirus 1
Tissue Distribution
Glycoproteins
Complement System Proteins
Membrane Proteins
Leukocytes
Growth
Proteins
factor H receptors

Keywords

  • C3 receptor
  • Complement
  • Complement receptor
  • Protein sequence homology

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Structure and specificity of complement receptors. / Sim, R. B.; Malhotra, V.; Day, A. J.; Erdei, A.

In: Immunology Letters, Vol. 14, No. 3, 1987, p. 183-190.

Research output: Contribution to journalArticle

Sim, R. B. ; Malhotra, V. ; Day, A. J. ; Erdei, A. / Structure and specificity of complement receptors. In: Immunology Letters. 1987 ; Vol. 14, No. 3. pp. 183-190.
@article{bf0c001a16ed491a9b95efea218b803b,
title = "Structure and specificity of complement receptors",
abstract = "Fifteen to 16 cell surface proteins which interact with soluble components of the complement system have now been identified. Most of these - CR1, CR2, CR3, {"}CR4{"}, DAF, HSV-1 c glycoprotein, Gp 45-70, p150,95, cell-surface Factor H, and a 90 kD protein - interact with C3 or C4 and their degradation products. Other receptors for C1q, Factor H, C5a, and the C5b-9 complex have been identified. Receptors for additional complement proteins such as Factor B or its fragments are likely to exist. Complement receptors have a wide tissue distribution and have major roles in (1) controlling the turnover of the complement system, and (2) regulating behaviour and growth of leukocytes.",
keywords = "C3 receptor, Complement, Complement receptor, Protein sequence homology",
author = "Sim, {R. B.} and V. Malhotra and Day, {A. J.} and A. Erdei",
year = "1987",
doi = "10.1016/0165-2478(87)90099-X",
language = "English",
volume = "14",
pages = "183--190",
journal = "Immunology Letters",
issn = "0165-2478",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - Structure and specificity of complement receptors

AU - Sim, R. B.

AU - Malhotra, V.

AU - Day, A. J.

AU - Erdei, A.

PY - 1987

Y1 - 1987

N2 - Fifteen to 16 cell surface proteins which interact with soluble components of the complement system have now been identified. Most of these - CR1, CR2, CR3, "CR4", DAF, HSV-1 c glycoprotein, Gp 45-70, p150,95, cell-surface Factor H, and a 90 kD protein - interact with C3 or C4 and their degradation products. Other receptors for C1q, Factor H, C5a, and the C5b-9 complex have been identified. Receptors for additional complement proteins such as Factor B or its fragments are likely to exist. Complement receptors have a wide tissue distribution and have major roles in (1) controlling the turnover of the complement system, and (2) regulating behaviour and growth of leukocytes.

AB - Fifteen to 16 cell surface proteins which interact with soluble components of the complement system have now been identified. Most of these - CR1, CR2, CR3, "CR4", DAF, HSV-1 c glycoprotein, Gp 45-70, p150,95, cell-surface Factor H, and a 90 kD protein - interact with C3 or C4 and their degradation products. Other receptors for C1q, Factor H, C5a, and the C5b-9 complex have been identified. Receptors for additional complement proteins such as Factor B or its fragments are likely to exist. Complement receptors have a wide tissue distribution and have major roles in (1) controlling the turnover of the complement system, and (2) regulating behaviour and growth of leukocytes.

KW - C3 receptor

KW - Complement

KW - Complement receptor

KW - Protein sequence homology

UR - http://www.scopus.com/inward/record.url?scp=0023139860&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023139860&partnerID=8YFLogxK

U2 - 10.1016/0165-2478(87)90099-X

DO - 10.1016/0165-2478(87)90099-X

M3 - Article

C2 - 3552967

AN - SCOPUS:0023139860

VL - 14

SP - 183

EP - 190

JO - Immunology Letters

JF - Immunology Letters

SN - 0165-2478

IS - 3

ER -