Structure and drug release of lamellar liquid crystals containing glycerol

M. Makai, E. Csányi, Zs Németh, J. Pálinkás, I. Erös

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

Lamellar lyotropic liquid crystalline (LLC) systems are thermodynamically stable, optically isotropic systems, which are formed with low energy input. New possibilities for the development of controlled drug delivery systems are inherent in these systems due to their stability and special skin-similarly structure. The present aim was to formulate multicomponent LLC systems with a relatively low surfactant content, composed of materials official in the European Pharmacopoeia 4th. Polarizing light microscopic examination of the samples was carried out, together with TEM observation of replicas produced by freeze-fractured technique for the purpose of demonstrating the presence of lamellar LC domains. Our LLC samples contained: Brij 96 (poly-oxyethylene-10-oleyl ether) with water, liquid petrolatum (LP) and glycerol in a given concentration range. The interlamellar repeated distance (dL) confirming the existence of a regular structure was determined by means of X-ray diffraction. The dL and G′values of the samples changed according to a maximum curve with increasing glycerol concentration up to 40% (w/w). A prolonged drug release was observed in case of the very water-soluble ephedrine hydrochloride and the same phenomena was observed in the case of tenoxicam, which is practically insoluble in water.

Original languageEnglish
Pages (from-to)95-107
Number of pages13
JournalInternational Journal of Pharmaceutics
Volume256
Issue number1-2
DOIs
Publication statusPublished - Apr 30 2003

Fingerprint

Liquid Crystals
Glycerol
tenoxicam
Water
Ephedrine
Mineral Oil
Pharmacopoeias
Drug Delivery Systems
Surface-Active Agents
X-Ray Diffraction
Ether
Observation
Light
Skin
Drug Liberation

Keywords

  • Controlled drug release
  • Cryo-TEM
  • Lamellar liquid crystals
  • Oscillating rheology
  • Polarizing light microscopy
  • X-ray diffraction

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Structure and drug release of lamellar liquid crystals containing glycerol. / Makai, M.; Csányi, E.; Németh, Zs; Pálinkás, J.; Erös, I.

In: International Journal of Pharmaceutics, Vol. 256, No. 1-2, 30.04.2003, p. 95-107.

Research output: Contribution to journalArticle

Makai, M. ; Csányi, E. ; Németh, Zs ; Pálinkás, J. ; Erös, I. / Structure and drug release of lamellar liquid crystals containing glycerol. In: International Journal of Pharmaceutics. 2003 ; Vol. 256, No. 1-2. pp. 95-107.
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