Structure-activity studies on the effects of atrial natriuretic peptide, brain natriuretic peptide and their analogs on fear-motivated learning behavior in rats

A. Bidzseranova, J. Gueron, G. Tóth, J. Varga, G. Telegdy

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Our previous studies have demonstrated that rat atrial natriuretic peptide (rANP 1-28) and porcine brain natriuretic peptide (pBNP 1-32) administered into the lateral brain facilitate the consolidation of a passive avoidance response and delay the extinction of an active avoidance response in fear-motivated learning in rats. To study the structure-activity relationships in the same learning processes, the effects of several fragments related to ANP and BNP were investigated following their intracerebroventricular administration to rats. The following peptides were studied: rANP 1-28, rANP 5-28, rANP 5-27, rANP 7-23 (ring), rANP 17-23, hANP 10-28, hANP 15-28, hANP 20-28, hANP 1-28, pBNP 1-32 and pBNP 7-32. The peptides were used in equimolar concentration. Two of the peptides studied, ANP 20-28 and ANP 17-23, were ineffective on the extinction of active avoidance behavior and on the consolidation of passive avoidance learning. They exhibited similar actions. The results showed that small fragments of ANP and BNP can carry the biological activity of ANP and BNP on the central nervous system (CNS). It is likely that the biological active center for ANP lies between amino acids 15 and 23 and it is suspected that the ring structure is not absolutely important for the CNS activity.

Original languageEnglish
Pages (from-to)61-65
Number of pages5
JournalNeuropeptides
Volume23
Issue number2
DOIs
Publication statusPublished - 1992

Fingerprint

Brain Natriuretic Peptide
Atrial Natriuretic Factor
Fear
Rats
Learning
Avoidance Learning
Neurology
Consolidation
Peptides
Central Nervous System
Structure-Activity Relationship
Bioactivity
Brain
Amino Acids
rat atrial natriuretic peptide

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Clinical Neurology
  • Neuroscience(all)
  • Cellular and Molecular Neuroscience

Cite this

Structure-activity studies on the effects of atrial natriuretic peptide, brain natriuretic peptide and their analogs on fear-motivated learning behavior in rats. / Bidzseranova, A.; Gueron, J.; Tóth, G.; Varga, J.; Telegdy, G.

In: Neuropeptides, Vol. 23, No. 2, 1992, p. 61-65.

Research output: Contribution to journalArticle

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