This paper surveys the relationships between the chemical structures and pharmacological activities of natural or semisynthetic 4,5α-epoxymorphinans, synthetic morphinans and benzomorphans. Substitution of the N-methyl group affords strong analgesics, opioid antagonists and mixed agonist-antagonists respectively. The role of opioid agonists and antagonists in the development of opioid receptor models is also discussed.
|Number of pages||18|
|Journal||Current medicinal chemistry|
|Publication status||Published - Jan 1 1995|
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery
- Organic Chemistry