Structure-activity relationships of synthetic and semisynthetic opioid agonists and antagonists

S. Furst, S. Hosztafi, T. Friedmann

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

This paper surveys the relationships between the chemical structures and pharmacological activities of natural or semisynthetic 4,5α-epoxymorphinans, synthetic morphinans and benzomorphans. Substitution of the N-methyl group affords strong analgesics, opioid antagonists and mixed agonist-antagonists respectively. The role of opioid agonists and antagonists in the development of opioid receptor models is also discussed.

Original languageEnglish
Pages (from-to)423-440
Number of pages18
JournalCurrent medicinal chemistry
Volume1
Issue number6
Publication statusPublished - Jan 1 1995

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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