Structure activity relationship in toxicology

Research output: Contribution to journalArticle

Abstract

One of the basic principles of the modern pharmacological research is that there is a close correlation between the chemical structure and the pharmacological effect. In contrast to pharmacology, in toxicology high doses of the drugs are used in order to provoke toxic symptoms generally realized through other receptors than the pharmacological effect. The evaluation of the structure activity relationship (SAR) in toxicology is hindered by the fact that it is not possible to establish in every case that the toxic effect 1. is developed by the original compound or its metabolite(s) 2. is realized through one or more receptors. Furthermore it is necessary to take into consideration that the studies in toxicology are not carried out with so many compounds as the studies in pharmacology and - horribile dictu - the toxicological data are not always public. Thus the prediction of the toxicity of a compound on the base of its chemical structure is difficult, and the prediction whether a new drug is toxic to such an extent that excludes its development, is impossible. What we can do is trying to predict - in the knowledge of the metabolism of the drug - its possible carcinogenic, hepatotoxic, CNS etc. toxic effect.

Original languageEnglish
Pages (from-to)47-50
Number of pages4
JournalActa Physiologica Hungarica
Volume83
Issue number1
Publication statusPublished - 1995

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Structure-Activity Relationship
Toxicology
Poisons
Pharmacology
Pharmaceutical Preparations
Research

Keywords

  • chemical structure
  • pharmacology
  • relationship
  • toxicology

ASJC Scopus subject areas

  • Physiology

Cite this

Structure activity relationship in toxicology. / Vereczkey, L.

In: Acta Physiologica Hungarica, Vol. 83, No. 1, 1995, p. 47-50.

Research output: Contribution to journalArticle

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