Structure-activity relationship in the effects of delta-sleep-inducing peptide (DSIP) on rat sleep

F. Obál, V. M. Kovalzon, V. N. Kalikhevich, A. Török, P. Alföldi, G. Sáry, M. Hajós, B. Penke

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Abstract

DSIP and its analogues, [D-Trp1]-DSIP, [D-Tyr1]-DSIP, and [D-Trp1]-DSIP1-6, were injected ICV (7 nmol/kg) into rats at dark onset, and the sleep-wake activity was recorded during the 12-hr dark period and the subsequent 12-hr light period. The effects were evaluated with respect to baseline records obtained after artificial CSF injections. DSIP did not increase sleep, whereas both [D-Trp1]-DSIP and [D-Tyr1]-DSIP promoted sleep in the first part of the night. [D-Trp1]-DSIP1-6 had a prompt arousing effect. It is suggested that the sleep-promoting analogues act by facilitating slight endogenous sleep tendencies at some time after dark onset, while DSIP is degraded quickly and is therefore not effective. The increase of W after [D-Trp1]-DSIP1-6 may indicate that DSIP contains a fragment with an arousing effect. The results corroborate the notion that the active DSIP molecule has a pseudo-cyclic structure.

Original languageEnglish
Pages (from-to)889-894
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume24
Issue number4
DOIs
Publication statusPublished - Apr 1986

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Keywords

  • DSIP
  • Sleep
  • Sleep factors

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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