Structural vascular changes in hypertension

Role of angiotensin II, dietary sodium supplementation, and sympathetic stimulation, alone and in combination in rats

Geza Simon, G. Illyés

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Elevated circulating angiotensin (Ang) II levels, dietary sodium, and sympathetic stimulation are recurrent themes of hypertension research, but their in vivo interaction in physiologically meaningful doses has not been adequately investigated. In this study, the interaction of a subpressor dose of Ang II (50 ng · kg-1 · min-1 SC), 2% NaCl diet, and sympathetic stimulation in the form of overnight cold exposure was investigated in the development of hypertension and of structural vascular changes in male Sprague-Dawley rats. There were 8 experimental groups: sham operation and treatment (control), Ang II, 2% NaCl diet, cold exposure (5°C), Ang II plus 2% NaCl diet, Ang II plus cold exposure, cold exposure plus 2% NaCl diet, and Ang II plus 2% NaCl diet plus cold exposure (triple treatment). For each group, the duration of treatment was 12 weeks. Morphometric measurements of maximally dilated, in situ fixed, second-order (250 to 320 μm OD), intermediate-size (100 to 150 μm OD), and small (50 to 100 μm OD) mesenteric arteries were performed, and wall-to-lumen ratios (W/L) were calculated. During the 12-week study, the blood pressure (BP) load (the area under the systolic BP curve) of rats receiving the combined treatment of Ang II and 2% NaCl diet was increased (P

Original languageEnglish
Pages (from-to)255-260
Number of pages6
JournalHypertension
Volume37
Issue number2 I
Publication statusPublished - 2001

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Dietary Sodium
Dietary Supplements
Angiotensin II
Blood Vessels
Hypertension
Diet
Blood Pressure
Mesenteric Arteries
Sprague Dawley Rats
Therapeutics
Placebos
Research

Keywords

  • Arteries
  • Circulation
  • Mesenteric arteries

ASJC Scopus subject areas

  • Internal Medicine

Cite this

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abstract = "Elevated circulating angiotensin (Ang) II levels, dietary sodium, and sympathetic stimulation are recurrent themes of hypertension research, but their in vivo interaction in physiologically meaningful doses has not been adequately investigated. In this study, the interaction of a subpressor dose of Ang II (50 ng · kg-1 · min-1 SC), 2{\%} NaCl diet, and sympathetic stimulation in the form of overnight cold exposure was investigated in the development of hypertension and of structural vascular changes in male Sprague-Dawley rats. There were 8 experimental groups: sham operation and treatment (control), Ang II, 2{\%} NaCl diet, cold exposure (5°C), Ang II plus 2{\%} NaCl diet, Ang II plus cold exposure, cold exposure plus 2{\%} NaCl diet, and Ang II plus 2{\%} NaCl diet plus cold exposure (triple treatment). For each group, the duration of treatment was 12 weeks. Morphometric measurements of maximally dilated, in situ fixed, second-order (250 to 320 μm OD), intermediate-size (100 to 150 μm OD), and small (50 to 100 μm OD) mesenteric arteries were performed, and wall-to-lumen ratios (W/L) were calculated. During the 12-week study, the blood pressure (BP) load (the area under the systolic BP curve) of rats receiving the combined treatment of Ang II and 2{\%} NaCl diet was increased (P",
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