Structural vascular changes in hypertension: Role of angiotensin II, dietary sodium supplementation, blood pressure, and time

G. Simon, G. Illyés, B. Csiky

Research output: Contribution to journalArticle

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Abstract

The dose and time dependence of angiotensin II (Ang II)-induced hypertension and structural vascular changes and the effect of dietary sodium supplementation on these relationships were investigated. Male Sprague- Dawley rats were treated with 50, 100, or 200 ng · kg-1 · min-1 Ang II subcutaneously for 4 or 12 weeks on normal sodium diet (0.7% NaCl) or with 50 ng · kg-1 · min-1 Ang II SC for 12 weeks on high sodium diet (2% NaCl). Additional rats were sham-operated and fed normal sodium (control rats) or high sodium diet. Plasma Ang II level of rats receiving 100 ng · kg-1 · min-1 Ang II for 4 weeks was 26±5 pg/mL (mean±SEM, n=7) compared with 11±2 pg/mL (n=15) in control rats (P-1 · min-1 Ang II for 12 weeks were examined to distinguish hypertrophy from hyperplasia of vascular muscle. Tail systolic blood pressure (BP) and W/L of resistance arteries of Ang II-treated rats increased in a dose-dependent manner. Treatment with 50 ng · kg-1 · min-1 Ang II for 12 weeks had no significant effect on BP but produced the same increase in W/L (+10%, n=8, P-1 · min-1 Ang II for 4 weeks (+9%, n=18, P- 1 · min-1 Ang II, it increased systolic BP by 31 mm Hg (P-1 · min-1 Ang II for 12 weeks, arterial smooth muscle cell thickness was increased without a change in the number of cell layers (hypertrophy). There was a dissociation between the average BP load (the area under the weekly systolic BP curve) of Ang II-treated rats and the W/L of their mesenteric resistance arteries. Ang II-induced hypertension and structural vascular changes are dose- and time-dependent and synergistically enhanced by dietary sodium supplementation. Dissociation between BP and vascular structure in Ang II-treated rats suggests that a direct trophic effect of Ang II may contribute to the development of structural vascular changes.

Original languageEnglish
Pages (from-to)654-660
Number of pages7
JournalHypertension
Volume32
Issue number4
Publication statusPublished - 1998

Fingerprint

Dietary Sodium
Dietary Supplements
Angiotensin II
Blood Vessels
Blood Pressure
Hypertension
Sodium
Diet
Hypertrophy
Mesenteric Arteries

Keywords

  • Arteries
  • Mesenteric circulation
  • Morphometry

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Structural vascular changes in hypertension : Role of angiotensin II, dietary sodium supplementation, blood pressure, and time. / Simon, G.; Illyés, G.; Csiky, B.

In: Hypertension, Vol. 32, No. 4, 1998, p. 654-660.

Research output: Contribution to journalArticle

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abstract = "The dose and time dependence of angiotensin II (Ang II)-induced hypertension and structural vascular changes and the effect of dietary sodium supplementation on these relationships were investigated. Male Sprague- Dawley rats were treated with 50, 100, or 200 ng · kg-1 · min-1 Ang II subcutaneously for 4 or 12 weeks on normal sodium diet (0.7{\%} NaCl) or with 50 ng · kg-1 · min-1 Ang II SC for 12 weeks on high sodium diet (2{\%} NaCl). Additional rats were sham-operated and fed normal sodium (control rats) or high sodium diet. Plasma Ang II level of rats receiving 100 ng · kg-1 · min-1 Ang II for 4 weeks was 26±5 pg/mL (mean±SEM, n=7) compared with 11±2 pg/mL (n=15) in control rats (P-1 · min-1 Ang II for 12 weeks were examined to distinguish hypertrophy from hyperplasia of vascular muscle. Tail systolic blood pressure (BP) and W/L of resistance arteries of Ang II-treated rats increased in a dose-dependent manner. Treatment with 50 ng · kg-1 · min-1 Ang II for 12 weeks had no significant effect on BP but produced the same increase in W/L (+10{\%}, n=8, P-1 · min-1 Ang II for 4 weeks (+9{\%}, n=18, P- 1 · min-1 Ang II, it increased systolic BP by 31 mm Hg (P-1 · min-1 Ang II for 12 weeks, arterial smooth muscle cell thickness was increased without a change in the number of cell layers (hypertrophy). There was a dissociation between the average BP load (the area under the weekly systolic BP curve) of Ang II-treated rats and the W/L of their mesenteric resistance arteries. Ang II-induced hypertension and structural vascular changes are dose- and time-dependent and synergistically enhanced by dietary sodium supplementation. Dissociation between BP and vascular structure in Ang II-treated rats suggests that a direct trophic effect of Ang II may contribute to the development of structural vascular changes.",
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