Structural study of α-lactose monohydrate subjected to microwave irradiation

Anikó Szepes, Anke Fiebig, J. Ulrich, P. Szabó-Révész

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The aim of this work was to investigate the influence of different levels of microwave irradiation on the structure and particle size characteristics of α-lactose monohydrate. The structural study of the samples was carried out by XRD, the presence of lactose polymorphs in the test samples was determined by DSC and the particle size distribution was measured by laser diffraction. The samples subjected to microwave irradiation retained their original X-ray patterns. No significant differences in thermal transition characteristics and particle size were observed. Hence, neither the occurrence of crystalline-amorphous transition resulted by microwave irradiation nor the presence of lactose polymorphs in the test samples can be assumed. The unmodified properties can be attributed to the fact that the water of crystallization is very difficult to remove from the crystal structure and is not free to move during microwave treatment, which results in stability to microwaves. Our results allow the conclusion that microwave processing of α-lactose monohydrate has no influence on further pharmaceutical technological properties, which are related to the structure and the particle size distribution of this substance.

Original languageEnglish
Pages (from-to)757-760
Number of pages4
JournalJournal of Thermal Analysis and Calorimetry
Volume89
Issue number3
DOIs
Publication statusPublished - Sep 2007

Fingerprint

lactose
Microwave irradiation
Lactose
Microwaves
Polymorphism
microwaves
Particle size analysis
irradiation
Particle size
particle size distribution
Drug products
Crystallization
Diffraction
Crystal structure
Crystalline materials
X rays
Lasers
Processing
Water
occurrences

Keywords

  • DSC
  • Lactose
  • Microwave
  • Particle size
  • X-ray powder diffraction

ASJC Scopus subject areas

  • Chemical Engineering(all)

Cite this

Structural study of α-lactose monohydrate subjected to microwave irradiation. / Szepes, Anikó; Fiebig, Anke; Ulrich, J.; Szabó-Révész, P.

In: Journal of Thermal Analysis and Calorimetry, Vol. 89, No. 3, 09.2007, p. 757-760.

Research output: Contribution to journalArticle

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AU - Ulrich, J.

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