Structural requirements of the binding of nonionic surfactants to sodium dodecylsulfate

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Abstract

The interaction of 24 nonionic surfactants (6 ethoxylated stearic acid derivatives, 10 ethoxylated fatty alcohols, and 8 ethoxylated anhydrosorbite derivatives) with the anionic surfactant sodium dodecylsulfate (SDS) was studied by reversed-phase chromatography, and the relative strength of interaction has been calculated. Principal component analysis (PCA) was used for the determination of molecular substructures and physicochemical parameters accounting for the interaction. Each nonionic surfactant interacted with SDS; the relative strength of interaction depended considerably on the molecular structure of surfactants. In each instance the SDS - surfactant complex was less hydrophobic than the surfactant itself. The result of PCA points to the involvement of both hydrophobic and hydrophilic forces in complex formation. The data also indicate that the apolar alkyl chain of SDS is probably bound to the hydrophobic moiety of surfactants, and the polar head group interacts with the hydrophilic ethylene oxide chain of nonionic surfactants. The strong interaction between SDS and nonionic surfactants suggests that this interaction may have a marked influence on the biological efficacy of any pharmaceutical, agrochemical formulations and cosmetics containing simultaneously both types of surfactants.

Original languageEnglish
Pages (from-to)524-528
Number of pages5
JournalQuantitative Structure-Activity Relationships
Volume14
Issue number6
DOIs
Publication statusPublished - 1995

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Nonionic surfactants
Surface-Active Agents
Surface active agents
Sodium
Principal component analysis
Fatty Alcohols
Agrochemicals
Derivatives
Ethylene Oxide
Stearic acid
Cosmetics
Anionic surfactants
Chromatography
Principal Component Analysis
Drug products
Molecular structure
Ethylene
Drug Compounding
Oxides
Reverse-Phase Chromatography

Keywords

  • Chromatography
  • Nonionic surfactants
  • Reversed-phase
  • Sodium dodecylsulfate

ASJC Scopus subject areas

  • Pharmacology

Cite this

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title = "Structural requirements of the binding of nonionic surfactants to sodium dodecylsulfate",
abstract = "The interaction of 24 nonionic surfactants (6 ethoxylated stearic acid derivatives, 10 ethoxylated fatty alcohols, and 8 ethoxylated anhydrosorbite derivatives) with the anionic surfactant sodium dodecylsulfate (SDS) was studied by reversed-phase chromatography, and the relative strength of interaction has been calculated. Principal component analysis (PCA) was used for the determination of molecular substructures and physicochemical parameters accounting for the interaction. Each nonionic surfactant interacted with SDS; the relative strength of interaction depended considerably on the molecular structure of surfactants. In each instance the SDS - surfactant complex was less hydrophobic than the surfactant itself. The result of PCA points to the involvement of both hydrophobic and hydrophilic forces in complex formation. The data also indicate that the apolar alkyl chain of SDS is probably bound to the hydrophobic moiety of surfactants, and the polar head group interacts with the hydrophilic ethylene oxide chain of nonionic surfactants. The strong interaction between SDS and nonionic surfactants suggests that this interaction may have a marked influence on the biological efficacy of any pharmaceutical, agrochemical formulations and cosmetics containing simultaneously both types of surfactants.",
keywords = "Chromatography, Nonionic surfactants, Reversed-phase, Sodium dodecylsulfate",
author = "E. Forg{\'a}cs and T. Cserh{\'a}ti",
year = "1995",
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T1 - Structural requirements of the binding of nonionic surfactants to sodium dodecylsulfate

AU - Forgács, E.

AU - Cserháti, T.

PY - 1995

Y1 - 1995

N2 - The interaction of 24 nonionic surfactants (6 ethoxylated stearic acid derivatives, 10 ethoxylated fatty alcohols, and 8 ethoxylated anhydrosorbite derivatives) with the anionic surfactant sodium dodecylsulfate (SDS) was studied by reversed-phase chromatography, and the relative strength of interaction has been calculated. Principal component analysis (PCA) was used for the determination of molecular substructures and physicochemical parameters accounting for the interaction. Each nonionic surfactant interacted with SDS; the relative strength of interaction depended considerably on the molecular structure of surfactants. In each instance the SDS - surfactant complex was less hydrophobic than the surfactant itself. The result of PCA points to the involvement of both hydrophobic and hydrophilic forces in complex formation. The data also indicate that the apolar alkyl chain of SDS is probably bound to the hydrophobic moiety of surfactants, and the polar head group interacts with the hydrophilic ethylene oxide chain of nonionic surfactants. The strong interaction between SDS and nonionic surfactants suggests that this interaction may have a marked influence on the biological efficacy of any pharmaceutical, agrochemical formulations and cosmetics containing simultaneously both types of surfactants.

AB - The interaction of 24 nonionic surfactants (6 ethoxylated stearic acid derivatives, 10 ethoxylated fatty alcohols, and 8 ethoxylated anhydrosorbite derivatives) with the anionic surfactant sodium dodecylsulfate (SDS) was studied by reversed-phase chromatography, and the relative strength of interaction has been calculated. Principal component analysis (PCA) was used for the determination of molecular substructures and physicochemical parameters accounting for the interaction. Each nonionic surfactant interacted with SDS; the relative strength of interaction depended considerably on the molecular structure of surfactants. In each instance the SDS - surfactant complex was less hydrophobic than the surfactant itself. The result of PCA points to the involvement of both hydrophobic and hydrophilic forces in complex formation. The data also indicate that the apolar alkyl chain of SDS is probably bound to the hydrophobic moiety of surfactants, and the polar head group interacts with the hydrophilic ethylene oxide chain of nonionic surfactants. The strong interaction between SDS and nonionic surfactants suggests that this interaction may have a marked influence on the biological efficacy of any pharmaceutical, agrochemical formulations and cosmetics containing simultaneously both types of surfactants.

KW - Chromatography

KW - Nonionic surfactants

KW - Reversed-phase

KW - Sodium dodecylsulfate

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