Of all the peripheral lymphoid tissues, spleen represents the earliest organ specialized to perform adaptive immune responses, and it has also preserved its basic structural organization in various vertebrate classes. Its architecture, as well as developmental properties, is strikingly different from other secondary lymphoid organs. Here we summarize the developmental regulation of its main tissue compartments in man and mouse during the prenatal and early postnatal period, with particular emphasis on its nonhemopoietic stromal constituents and their macrodomains.
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)