Structural evolution of the spleen in man and mouse

Péter Balogh, Árpád Lábadi

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Citations (Scopus)


Of all the peripheral lymphoid tissues, spleen represents the earliest organ specialized to perform adaptive immune responses, and it has also preserved its basic structural organization in various vertebrate classes. Its architecture, as well as developmental properties, is strikingly different from other secondary lymphoid organs. Here we summarize the developmental regulation of its main tissue compartments in man and mouse during the prenatal and early postnatal period, with particular emphasis on its nonhemopoietic stromal constituents and their macrodomains.

Original languageEnglish
Title of host publicationDevelopmental Biology of Peripheral Lymphoid Organs
PublisherSpringer Berlin Heidelberg
Number of pages21
ISBN (Print)9783642144288
Publication statusPublished - Dec 1 2011

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

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  • Cite this

    Balogh, P., & Lábadi, Á. (2011). Structural evolution of the spleen in man and mouse. In Developmental Biology of Peripheral Lymphoid Organs (pp. 121-141). Springer Berlin Heidelberg.