Structural changes in the mouse thymus and lymph node after emetine treatment

I. Olá, F. Antoni, G. Bánfalvi, I. Csuka, N. G. Luat, I. Törõ

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The effect of emetine which is a potent immunosuppresant was studied on the thymus and lymph node. The subcapsular zone of the thymus was depleted and large number of adherent cells accumulated in this thymic region. The medulla enlarged but the cortico-medullary border remained distinct. In the paracortex (T dependent area) of the lymph node many non-lymphoid pyroninophil cells appeared which is followed by an increased cell proliferation 24 hours after emetine injection. 48-60 hours after administration many macrophage-like cells appeared in the medullary sinuses. This macrophage invasion precedes the adherent cell accumulation in the subcapsular zone of the thymus suggesting a possible non-lymphoid (adherent) cell migration from the lymph node's paracortex to the thymus.

Original languageEnglish
Pages (from-to)385-395
Number of pages11
JournalDevelopmental and Comparative Immunology
Volume12
Issue number2
DOIs
Publication statusPublished - 1988

Fingerprint

Emetine
Thymus Gland
Lymph Nodes
Macrophages
Therapeutics
Cell Movement
Cell Count
Cell Proliferation
Injections

ASJC Scopus subject areas

  • Developmental Biology
  • Immunology

Cite this

Structural changes in the mouse thymus and lymph node after emetine treatment. / Olá, I.; Antoni, F.; Bánfalvi, G.; Csuka, I.; Luat, N. G.; Törõ, I.

In: Developmental and Comparative Immunology, Vol. 12, No. 2, 1988, p. 385-395.

Research output: Contribution to journalArticle

Olá, I. ; Antoni, F. ; Bánfalvi, G. ; Csuka, I. ; Luat, N. G. ; Törõ, I. / Structural changes in the mouse thymus and lymph node after emetine treatment. In: Developmental and Comparative Immunology. 1988 ; Vol. 12, No. 2. pp. 385-395.
@article{7af171cf9d9c4f41a89a5eb3fd511ec9,
title = "Structural changes in the mouse thymus and lymph node after emetine treatment",
abstract = "The effect of emetine which is a potent immunosuppresant was studied on the thymus and lymph node. The subcapsular zone of the thymus was depleted and large number of adherent cells accumulated in this thymic region. The medulla enlarged but the cortico-medullary border remained distinct. In the paracortex (T dependent area) of the lymph node many non-lymphoid pyroninophil cells appeared which is followed by an increased cell proliferation 24 hours after emetine injection. 48-60 hours after administration many macrophage-like cells appeared in the medullary sinuses. This macrophage invasion precedes the adherent cell accumulation in the subcapsular zone of the thymus suggesting a possible non-lymphoid (adherent) cell migration from the lymph node's paracortex to the thymus.",
author = "I. Ol{\'a} and F. Antoni and G. B{\'a}nfalvi and I. Csuka and Luat, {N. G.} and I. T{\"o}r{\~o}",
year = "1988",
doi = "10.1016/0145-305X(88)90013-4",
language = "English",
volume = "12",
pages = "385--395",
journal = "Developmental and Comparative Immunology",
issn = "0145-305X",
publisher = "Elsevier Limited",
number = "2",

}

TY - JOUR

T1 - Structural changes in the mouse thymus and lymph node after emetine treatment

AU - Olá, I.

AU - Antoni, F.

AU - Bánfalvi, G.

AU - Csuka, I.

AU - Luat, N. G.

AU - Törõ, I.

PY - 1988

Y1 - 1988

N2 - The effect of emetine which is a potent immunosuppresant was studied on the thymus and lymph node. The subcapsular zone of the thymus was depleted and large number of adherent cells accumulated in this thymic region. The medulla enlarged but the cortico-medullary border remained distinct. In the paracortex (T dependent area) of the lymph node many non-lymphoid pyroninophil cells appeared which is followed by an increased cell proliferation 24 hours after emetine injection. 48-60 hours after administration many macrophage-like cells appeared in the medullary sinuses. This macrophage invasion precedes the adherent cell accumulation in the subcapsular zone of the thymus suggesting a possible non-lymphoid (adherent) cell migration from the lymph node's paracortex to the thymus.

AB - The effect of emetine which is a potent immunosuppresant was studied on the thymus and lymph node. The subcapsular zone of the thymus was depleted and large number of adherent cells accumulated in this thymic region. The medulla enlarged but the cortico-medullary border remained distinct. In the paracortex (T dependent area) of the lymph node many non-lymphoid pyroninophil cells appeared which is followed by an increased cell proliferation 24 hours after emetine injection. 48-60 hours after administration many macrophage-like cells appeared in the medullary sinuses. This macrophage invasion precedes the adherent cell accumulation in the subcapsular zone of the thymus suggesting a possible non-lymphoid (adherent) cell migration from the lymph node's paracortex to the thymus.

UR - http://www.scopus.com/inward/record.url?scp=0023972955&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023972955&partnerID=8YFLogxK

U2 - 10.1016/0145-305X(88)90013-4

DO - 10.1016/0145-305X(88)90013-4

M3 - Article

VL - 12

SP - 385

EP - 395

JO - Developmental and Comparative Immunology

JF - Developmental and Comparative Immunology

SN - 0145-305X

IS - 2

ER -