Structural changes in silicon rubber peritoneal dialysis catheters in patients using mupirocin at the exit site

M. Khandelwal, S. Bailey, S. Izatt, M. Chu, S. Vas, J. Bargman, D. G. Oreopoulos

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Structural damage to polyurethane PD (peritoneal dialysis) catheters in patients using mupirocin ointment is widely appreciated, but damage to silicon rubber PD catheters is less well described. Ten catheters (6.6%) out of 152 were found to have structural alterations such as opacification, ballooning, thinning, and rupture. The duration of PD in these 10 patients ranged from 23 months to 80 months (mean duration 51.1 months). The frequency of mupirocin application varied from daily (2 cases) to 2-3 times per week (7 cases). In eight catheters opacification occurred at the exit site whereas one catheter showed opacification midway between the exit site and the titanium adaptor. One catheter showed opacification, ballooning, and thinning at the exit site ruptured in the form of two slit-like openings. In conclusion, various structural changes such as opacification, ballooning or thinning were seen in 6.6% of silicon rubber PD catheters in patients using mupirocin at the exit site. Although the mechanism remains elusive, mupirocin or the antiseptic solution alone or in combination may be contributory. We believe that this is an under-reported complication and encourage other health care givers to incorportate a search for such changes during clinic visits.

Original languageEnglish
Pages (from-to)913-917
Number of pages5
JournalInternational Journal of Artificial Organs
Volume26
Issue number10
Publication statusPublished - Oct 2003

Fingerprint

Mupirocin
Dialysis
Catheters
Rubber
Peritoneal Dialysis
Silicon
Local Anti-Infective Agents
Polyurethanes
Ambulatory Care
Ointments
Titanium
Health care
Caregivers
Rupture
Delivery of Health Care

Keywords

  • Mupirocin
  • Peritoneal catheter
  • Peritoneal dialysis
  • Polyurethane
  • Silicon rubber

ASJC Scopus subject areas

  • Biophysics

Cite this

Khandelwal, M., Bailey, S., Izatt, S., Chu, M., Vas, S., Bargman, J., & Oreopoulos, D. G. (2003). Structural changes in silicon rubber peritoneal dialysis catheters in patients using mupirocin at the exit site. International Journal of Artificial Organs, 26(10), 913-917.

Structural changes in silicon rubber peritoneal dialysis catheters in patients using mupirocin at the exit site. / Khandelwal, M.; Bailey, S.; Izatt, S.; Chu, M.; Vas, S.; Bargman, J.; Oreopoulos, D. G.

In: International Journal of Artificial Organs, Vol. 26, No. 10, 10.2003, p. 913-917.

Research output: Contribution to journalArticle

Khandelwal, M, Bailey, S, Izatt, S, Chu, M, Vas, S, Bargman, J & Oreopoulos, DG 2003, 'Structural changes in silicon rubber peritoneal dialysis catheters in patients using mupirocin at the exit site', International Journal of Artificial Organs, vol. 26, no. 10, pp. 913-917.
Khandelwal, M. ; Bailey, S. ; Izatt, S. ; Chu, M. ; Vas, S. ; Bargman, J. ; Oreopoulos, D. G. / Structural changes in silicon rubber peritoneal dialysis catheters in patients using mupirocin at the exit site. In: International Journal of Artificial Organs. 2003 ; Vol. 26, No. 10. pp. 913-917.
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