The enantiomers of 1-(α-aminobenzyl)-2-naphthol and 2-(α-aminobenzyl)-1-naphthol analogs were separated isothermally on a celllulose-tris-3,5-dimethylphenyl carbamate-based chiral stationary phase (Chiralcel OD-H), at 10°C increments in the range of 5-35°C, using n-hexane/2-propanol/diethylamine as mobile phase. The mobile phase composition and temperature were varied to achieve baseline resolutions in a single chromatographic run. The dependence of the natural logarithms of selectivity factors, In α, on the inverse of temperature, 1/T, was used to determine the thermodynamic data of the enantiomers. The thermodynamic data revealed that all the compounds in this study separate via the same enthalpy-driven chiral recognition mechanism.
- 1-(α-Aminobenzyl)-2-naphthol analogs
- 2-(α-Aminobenzyl)-1-naphthol analogs
- Enantiomer separation
- Temperature effect
ASJC Scopus subject areas
- Analytical Chemistry
- Filtration and Separation