Structural analysis of oval-cell-mediated liver regeneration in rats

Katalin Dezso, Veronika Papp, Edina Bugyik, H. Hegyesi, G. Sáfrány, Csaba Bödör, P. Nagy, S. Paku

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

We have analyzed the architectural aspects of progenitor-cell-driven regenerative growth in rat liver by applying the 2-acetaminofluorene/partial hepatectomy experimental model. The regeneration is initiated by the proliferation of so-called oval cells. The oval cells at the proximal tips of the ductules have a more differentiated phenotype and higher proliferative rate. This preferential growth results in the formation of a seemingly random collection of small hepatocytes, called foci. These foci have no clonal origin, but possess a highly organized structure, which shows similarities to normal hepatic parenchyma. Therefore, they can easily remodel into the lobular structure. Eventually, the regenerated liver is constructed by enlarged hepatic lobules; no new lobules are formed during this process. The foci of the Solt-Farber experimental hepatocarcinogenesis model have identical morphological features; accordingly, they also represent only regenerative, not neoplastic, growth. Conclusion: Progenitor-cell-driven liver regeneration is a well-designed, highly organized tissue reaction, and better comprehension of the architectural events may help us to recognize this process and understand its role in physiological and pathological reactions.

Original languageEnglish
Pages (from-to)1457-1467
Number of pages11
JournalHepatology
Volume56
Issue number4
DOIs
Publication statusPublished - Oct 2012

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Liver Regeneration
Liver
Theoretical Models
Stem Cells
Growth
Hepatectomy
Regeneration
Hepatocytes
Phenotype

ASJC Scopus subject areas

  • Hepatology

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Structural analysis of oval-cell-mediated liver regeneration in rats. / Dezso, Katalin; Papp, Veronika; Bugyik, Edina; Hegyesi, H.; Sáfrány, G.; Bödör, Csaba; Nagy, P.; Paku, S.

In: Hepatology, Vol. 56, No. 4, 10.2012, p. 1457-1467.

Research output: Contribution to journalArticle

Dezso, Katalin ; Papp, Veronika ; Bugyik, Edina ; Hegyesi, H. ; Sáfrány, G. ; Bödör, Csaba ; Nagy, P. ; Paku, S. / Structural analysis of oval-cell-mediated liver regeneration in rats. In: Hepatology. 2012 ; Vol. 56, No. 4. pp. 1457-1467.
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