Ausgeprägte Synergie zwischen Hyperthermie und moduliertem elektromagnetischem Feld bei der Abtötung von Tumorzellen

Translated title of the contribution: Strong synergy of heat and modulated electromagnetic field in tumor cell killing

Gabor Andocs, Helmut Renner, Lajos Balogh, Laszlo Fonyad, Csaba Jakab, Andras Szasz

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Background and Purpose: Hyperthermia is an emerging complementary method in radiooncology. Despite many positive studies and comprehensive reviews, the method is not widely accepted as a combination to radiotherapy. Modulated electrohyperthermia (mEHT; capacitive, electric field modulated, 13.56 MHz) has been used in clinical practice for almost 2 decades in Germany, Austria and Hungary. This in vivo study in nude mice xenograft tumors compares mEHT with "classic" radiative hyperthermia (radHT). Material and Methods: Nude mice were xenografted with HT29 human colorectal carcinoma cells. 28 mice in four groups with seven animals each and two tumors per animal (totally 56 tumors) were included in the present study: group 1 as untreated control; group 2 treated with radHT at 42 °C; group 3 treated with mEHT at identical 42 °C; group 4 treated with mEHT at 38 °C (by intensively cooling down the tumor). 24 h after treatment, animals were sacrificed and the tumor cross sections studied by precise morphological methods for the respective relative amount of "dead" tumor cells. Results: The effect of mEHT established a double effect as a synergy between the purely thermal (temperature-dependent) and nonthermal (not directly temperature-dependent) effects. The solely thermal enhancement ratio (TER) of cell killing was shown to be 2.9. The field enhancement ratio (FER) at a constant temperature of 42 °C was measured as 3.2. Their complex application significantly increased the therapeutic enhancement to 9.4. Conclusion: mEHT had a remarkable cancer cell-killing effect in a nude mice xenograft model.

Original languageGerman
Pages (from-to)120-126
Number of pages7
JournalStrahlentherapie und Onkologie
Volume185
Issue number2
DOIs
Publication statusPublished - Feb 2009

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Keywords

  • Bioelectromagnetics
  • Hyperthermia
  • Modulated electric field
  • Tumor treatment

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Oncology

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