Strong relationship between NREM sleep, epilepsy and plastic functions — A conceptual review on the neurophysiology background

P. Halász, R. Bódizs, Przemysla Péter Ujma, Dániel Fabó, A. Szűcs

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

The aim of this review is to summarize and discuss the strong bond between NREM sleep and epilepsy underlain by the shared link and effect on brain plasticity. Beyond the seizure occurrence rate, sleep relatedness may manifest in the enhancement of interictal epileptic discharges (spikes and pathological ripples). The number of the discharges as well as their propagation increase during NREM sleep, unmasking the epileptic network that is hidden during wakefulness. The interictal epileptic discharges associate with different sleep constituents (sleep slow waves, spindling and high frequency oscillations); known to play essential role in memory and learning. We highlight three major groups of epilepsies, in which sleep-related plastic functions suffer an epileptic derailment. In absence epilepsy mainly involving the thalamo-cortical system, sleep spindles transform to generalized spike-wave activity. In mesio-temporal epilepsy affecting the hippocampal declarative memory system, the sharp wave ripples derail to dysfunctional epileptic oscillations (spikes and pathological ripples). Idiopathic childhood epilepsies affecting the perisylvian network may progress to catastrophic status electricus during NREM sleep. In these major epilepsies, NREM sleep has a pivotal role in the development and course of the disorder. Epilepsy is born in-, and exhibits its pathological properties during NREM sleep. Interictal discharges are important causative agents in this process.

Original languageEnglish
Pages (from-to)95-105
Number of pages11
JournalEpilepsy Research
Volume150
DOIs
Publication statusPublished - Feb 1 2019

Fingerprint

Neurophysiology
Plastics
Epilepsy
Sleep
Tonic-Clonic Epilepsy
Radio Waves
Absence Epilepsy
Wakefulness
Seizures
Learning

Keywords

  • Brain plasticity
  • Epileptic derailment
  • Interictal epileptic activity
  • NREM sleep
  • Sleep-related epilepsy
  • System epilepsy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Strong relationship between NREM sleep, epilepsy and plastic functions — A conceptual review on the neurophysiology background. / Halász, P.; Bódizs, R.; Ujma, Przemysla Péter; Fabó, Dániel; Szűcs, A.

In: Epilepsy Research, Vol. 150, 01.02.2019, p. 95-105.

Research output: Contribution to journalReview article

@article{d71723ff06b94b3fa459fb14860d3c22,
title = "Strong relationship between NREM sleep, epilepsy and plastic functions — A conceptual review on the neurophysiology background",
abstract = "The aim of this review is to summarize and discuss the strong bond between NREM sleep and epilepsy underlain by the shared link and effect on brain plasticity. Beyond the seizure occurrence rate, sleep relatedness may manifest in the enhancement of interictal epileptic discharges (spikes and pathological ripples). The number of the discharges as well as their propagation increase during NREM sleep, unmasking the epileptic network that is hidden during wakefulness. The interictal epileptic discharges associate with different sleep constituents (sleep slow waves, spindling and high frequency oscillations); known to play essential role in memory and learning. We highlight three major groups of epilepsies, in which sleep-related plastic functions suffer an epileptic derailment. In absence epilepsy mainly involving the thalamo-cortical system, sleep spindles transform to generalized spike-wave activity. In mesio-temporal epilepsy affecting the hippocampal declarative memory system, the sharp wave ripples derail to dysfunctional epileptic oscillations (spikes and pathological ripples). Idiopathic childhood epilepsies affecting the perisylvian network may progress to catastrophic status electricus during NREM sleep. In these major epilepsies, NREM sleep has a pivotal role in the development and course of the disorder. Epilepsy is born in-, and exhibits its pathological properties during NREM sleep. Interictal discharges are important causative agents in this process.",
keywords = "Brain plasticity, Epileptic derailment, Interictal epileptic activity, NREM sleep, Sleep-related epilepsy, System epilepsy",
author = "P. Hal{\'a}sz and R. B{\'o}dizs and Ujma, {Przemysla P{\'e}ter} and D{\'a}niel Fab{\'o} and A. Szűcs",
year = "2019",
month = "2",
day = "1",
doi = "10.1016/j.eplepsyres.2018.11.008",
language = "English",
volume = "150",
pages = "95--105",
journal = "Epilepsy Research",
issn = "0920-1211",
publisher = "Elsevier",

}

TY - JOUR

T1 - Strong relationship between NREM sleep, epilepsy and plastic functions — A conceptual review on the neurophysiology background

AU - Halász, P.

AU - Bódizs, R.

AU - Ujma, Przemysla Péter

AU - Fabó, Dániel

AU - Szűcs, A.

PY - 2019/2/1

Y1 - 2019/2/1

N2 - The aim of this review is to summarize and discuss the strong bond between NREM sleep and epilepsy underlain by the shared link and effect on brain plasticity. Beyond the seizure occurrence rate, sleep relatedness may manifest in the enhancement of interictal epileptic discharges (spikes and pathological ripples). The number of the discharges as well as their propagation increase during NREM sleep, unmasking the epileptic network that is hidden during wakefulness. The interictal epileptic discharges associate with different sleep constituents (sleep slow waves, spindling and high frequency oscillations); known to play essential role in memory and learning. We highlight three major groups of epilepsies, in which sleep-related plastic functions suffer an epileptic derailment. In absence epilepsy mainly involving the thalamo-cortical system, sleep spindles transform to generalized spike-wave activity. In mesio-temporal epilepsy affecting the hippocampal declarative memory system, the sharp wave ripples derail to dysfunctional epileptic oscillations (spikes and pathological ripples). Idiopathic childhood epilepsies affecting the perisylvian network may progress to catastrophic status electricus during NREM sleep. In these major epilepsies, NREM sleep has a pivotal role in the development and course of the disorder. Epilepsy is born in-, and exhibits its pathological properties during NREM sleep. Interictal discharges are important causative agents in this process.

AB - The aim of this review is to summarize and discuss the strong bond between NREM sleep and epilepsy underlain by the shared link and effect on brain plasticity. Beyond the seizure occurrence rate, sleep relatedness may manifest in the enhancement of interictal epileptic discharges (spikes and pathological ripples). The number of the discharges as well as their propagation increase during NREM sleep, unmasking the epileptic network that is hidden during wakefulness. The interictal epileptic discharges associate with different sleep constituents (sleep slow waves, spindling and high frequency oscillations); known to play essential role in memory and learning. We highlight three major groups of epilepsies, in which sleep-related plastic functions suffer an epileptic derailment. In absence epilepsy mainly involving the thalamo-cortical system, sleep spindles transform to generalized spike-wave activity. In mesio-temporal epilepsy affecting the hippocampal declarative memory system, the sharp wave ripples derail to dysfunctional epileptic oscillations (spikes and pathological ripples). Idiopathic childhood epilepsies affecting the perisylvian network may progress to catastrophic status electricus during NREM sleep. In these major epilepsies, NREM sleep has a pivotal role in the development and course of the disorder. Epilepsy is born in-, and exhibits its pathological properties during NREM sleep. Interictal discharges are important causative agents in this process.

KW - Brain plasticity

KW - Epileptic derailment

KW - Interictal epileptic activity

KW - NREM sleep

KW - Sleep-related epilepsy

KW - System epilepsy

UR - http://www.scopus.com/inward/record.url?scp=85060765904&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060765904&partnerID=8YFLogxK

U2 - 10.1016/j.eplepsyres.2018.11.008

DO - 10.1016/j.eplepsyres.2018.11.008

M3 - Review article

C2 - 30712997

AN - SCOPUS:85060765904

VL - 150

SP - 95

EP - 105

JO - Epilepsy Research

JF - Epilepsy Research

SN - 0920-1211

ER -