Strong links are important, but weak links stabilize them

Research output: Contribution to journalShort survey

97 Citations (Scopus)

Abstract

Recently, a highly uneven distribution of metabolic network fluxes has been described in Escherichia coli that defines a high-flux backbone containing the most important (and most familiar) metabolic reactions. These findings might lead to a better understanding of the organization of the minimal gene set, and to a novel explanation for the allometric scaling laws. The scale-free distribution of the metabolic fluxes of E. coli highlights the importance of weak links in metabolic, and other, networks. Several proven examples show that weak links might have a general role in the stabilization of a variety of complex systems and, in addition, provide novel interpretations of the role of water in the potential energy landscape of the protein-folding process.

Original languageEnglish
Pages (from-to)331-334
Number of pages4
JournalTrends in Biochemical Sciences
Volume29
Issue number7
DOIs
Publication statusPublished - Jul 2004

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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