Stroke prevention with the angiotensin II type 1-receptor blocker candesartan in elderly patients with isolated systolic hypertension

The study on cognition and prognosis in the elderly (SCOPE)

Vasilios Papademetriou, C. Farsang, Dag Elmfeldt, Albert Hofman, Hans Lithell, Bertil Olofsson, Ingmar Skoog, Peter Trenkwalder, Alberto Zanchetti

Research output: Contribution to journalArticle

163 Citations (Scopus)

Abstract

The aim of this study was to test the hypothesis that the angiotensin II type 1 receptor blocker (ARB) candesartan can reduce the risk of stroke in elderly patients with isolated systolic hypertension (ISH). Isolated systolic hypertension is the predominant form of hypertension in the elderly, and stroke is the most common cardiovascular (CV) complication. In the Study on Cognition and Prognosis in the Elderly (SCOPE), 4,964 patients age 70 to 89 years were randomly assigned to double-blind candesartan or placebo with open-label antihypertensive therapy (mostly thiazide diuretics) added as needed to control blood pressure. Of the 4,964 patients, 1,518 had ISH (systolic blood pressure >160 mm Hg and diastolic blood pressure

Original languageEnglish
Pages (from-to)1175-1180
Number of pages6
JournalJournal of the American College of Cardiology
Volume44
Issue number6
DOIs
Publication statusPublished - Sep 15 2004

Fingerprint

Angiotensin II Type 1 Receptor Blockers
Cognition
Stroke
Blood Pressure
Hypertension
Sodium Chloride Symporter Inhibitors
Antihypertensive Agents
Placebos
candesartan

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Stroke prevention with the angiotensin II type 1-receptor blocker candesartan in elderly patients with isolated systolic hypertension : The study on cognition and prognosis in the elderly (SCOPE). / Papademetriou, Vasilios; Farsang, C.; Elmfeldt, Dag; Hofman, Albert; Lithell, Hans; Olofsson, Bertil; Skoog, Ingmar; Trenkwalder, Peter; Zanchetti, Alberto.

In: Journal of the American College of Cardiology, Vol. 44, No. 6, 15.09.2004, p. 1175-1180.

Research output: Contribution to journalArticle

Papademetriou, Vasilios ; Farsang, C. ; Elmfeldt, Dag ; Hofman, Albert ; Lithell, Hans ; Olofsson, Bertil ; Skoog, Ingmar ; Trenkwalder, Peter ; Zanchetti, Alberto. / Stroke prevention with the angiotensin II type 1-receptor blocker candesartan in elderly patients with isolated systolic hypertension : The study on cognition and prognosis in the elderly (SCOPE). In: Journal of the American College of Cardiology. 2004 ; Vol. 44, No. 6. pp. 1175-1180.
@article{7b8aa2ec9db1406489862405745965b4,
title = "Stroke prevention with the angiotensin II type 1-receptor blocker candesartan in elderly patients with isolated systolic hypertension: The study on cognition and prognosis in the elderly (SCOPE)",
abstract = "The aim of this study was to test the hypothesis that the angiotensin II type 1 receptor blocker (ARB) candesartan can reduce the risk of stroke in elderly patients with isolated systolic hypertension (ISH). Isolated systolic hypertension is the predominant form of hypertension in the elderly, and stroke is the most common cardiovascular (CV) complication. In the Study on Cognition and Prognosis in the Elderly (SCOPE), 4,964 patients age 70 to 89 years were randomly assigned to double-blind candesartan or placebo with open-label antihypertensive therapy (mostly thiazide diuretics) added as needed to control blood pressure. Of the 4,964 patients, 1,518 had ISH (systolic blood pressure >160 mm Hg and diastolic blood pressure",
author = "Vasilios Papademetriou and C. Farsang and Dag Elmfeldt and Albert Hofman and Hans Lithell and Bertil Olofsson and Ingmar Skoog and Peter Trenkwalder and Alberto Zanchetti",
year = "2004",
month = "9",
day = "15",
doi = "10.1016/j.jacc.2004.06.034",
language = "English",
volume = "44",
pages = "1175--1180",
journal = "Journal of the American College of Cardiology",
issn = "0735-1097",
publisher = "Elsevier USA",
number = "6",

}

TY - JOUR

T1 - Stroke prevention with the angiotensin II type 1-receptor blocker candesartan in elderly patients with isolated systolic hypertension

T2 - The study on cognition and prognosis in the elderly (SCOPE)

AU - Papademetriou, Vasilios

AU - Farsang, C.

AU - Elmfeldt, Dag

AU - Hofman, Albert

AU - Lithell, Hans

AU - Olofsson, Bertil

AU - Skoog, Ingmar

AU - Trenkwalder, Peter

AU - Zanchetti, Alberto

PY - 2004/9/15

Y1 - 2004/9/15

N2 - The aim of this study was to test the hypothesis that the angiotensin II type 1 receptor blocker (ARB) candesartan can reduce the risk of stroke in elderly patients with isolated systolic hypertension (ISH). Isolated systolic hypertension is the predominant form of hypertension in the elderly, and stroke is the most common cardiovascular (CV) complication. In the Study on Cognition and Prognosis in the Elderly (SCOPE), 4,964 patients age 70 to 89 years were randomly assigned to double-blind candesartan or placebo with open-label antihypertensive therapy (mostly thiazide diuretics) added as needed to control blood pressure. Of the 4,964 patients, 1,518 had ISH (systolic blood pressure >160 mm Hg and diastolic blood pressure

AB - The aim of this study was to test the hypothesis that the angiotensin II type 1 receptor blocker (ARB) candesartan can reduce the risk of stroke in elderly patients with isolated systolic hypertension (ISH). Isolated systolic hypertension is the predominant form of hypertension in the elderly, and stroke is the most common cardiovascular (CV) complication. In the Study on Cognition and Prognosis in the Elderly (SCOPE), 4,964 patients age 70 to 89 years were randomly assigned to double-blind candesartan or placebo with open-label antihypertensive therapy (mostly thiazide diuretics) added as needed to control blood pressure. Of the 4,964 patients, 1,518 had ISH (systolic blood pressure >160 mm Hg and diastolic blood pressure

UR - http://www.scopus.com/inward/record.url?scp=4444236607&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4444236607&partnerID=8YFLogxK

U2 - 10.1016/j.jacc.2004.06.034

DO - 10.1016/j.jacc.2004.06.034

M3 - Article

VL - 44

SP - 1175

EP - 1180

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

SN - 0735-1097

IS - 6

ER -