Stress on redox

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41 Citations (Scopus)

Abstract

Redox imbalance in the endoplasmic reticulum lumen is the most frequent cause of endoplasmic reticulum stress and consequent apoptosis. The mechanism involves the impairment of oxidative protein folding, the accumulation of unfolded/misfolded proteins in the lumen and the initiation of the unfolded protein response. The participation of several redox systems (glutathione, ascorbate, FAD, tocopherol, vitamin K) has been demonstrated in the process. Recent findings have attracted attention to the possible mechanistic role of luminal pyridine nucleotides in the endoplasmic reticulum stress. The aim of this minireview is to summarize the luminal redox systems and the redox sensing mechanisms of the endoplasmic reticulum.

Original languageEnglish
Pages (from-to)3634-3640
Number of pages7
JournalFEBS letters
Volume581
Issue number19
DOIs
Publication statusPublished - Jul 31 2007

Keywords

  • Ascorbate
  • Endoplasmic reticulum
  • Glutathione
  • NADPH
  • Oxidative protein folding
  • Unfolded protein response

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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