Stress-induced expression of co-localized neuropeptides in hypothalamic and amygdaloid neurons

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Abstract

This short review summarizes the effect of various stressful stimuli on the expression of neuropeptides which co-localize in corticotrophin releasing hormone (CRH)-synthesizing neurons in the hypothalamic paraventricular nucleus, as well as in oxytocin and vasopressin neurons in the supraoptic nucleus. Stress-induced changes failed to act on CRH neurons in the central amygdaloid nucleus but formalin-evoked pain enhanced galanin mRNA expression in the medial subdivision of this nucleus. Changes in the expression of enkephalin, galanin, dynorphin and cholecystokinin mRNA in response to restraint and formalin-induced pain are documented in hypothalamic and amygdaloid nuclei by in situ hybridization histochemical technique. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)161-166
Number of pages6
JournalEuropean Journal of Pharmacology
Volume405
Issue number1-3
DOIs
Publication statusPublished - Sep 29 2000

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Keywords

  • Amygdaloid nucleus, central
  • Neuropeptide
  • Paraventricular nucleus
  • Stressful stimuli
  • Supraoptic nucleus
  • c-fos

ASJC Scopus subject areas

  • Pharmacology

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