Stress-induced activation of neurons in the ventromedial arcuate nucleus: A blood-brain-CSF interface of the hypothalamus

Research output: Chapter in Book/Report/Conference proceedingConference contribution

24 Citations (Scopus)

Abstract

In response to a pain-related acute stress, the expression of c-fos protein (Fos), a marker of acute neuronal excitation, was investigated in the hypothalamus of rats. Few Fos-immunopositive cells were seen 15 min after a single subcutaneous injection of 4% formalin in the hypothalamus, but only in the paraventricular nucleus (PVN). Fifteen minutes later, a high number of parvocellular neurons of the PVN showed Fos expression. By 60 min after injection, strong immunoreactivity appeared in the arcuate nucleus, but the Fos-positive neurons distributed almost exclusively in the ventromedial subdivision of the nucleus. Neurons in this part of the arcuate nucleus express mainly neuropeptide Y (NPY) that projects to the medial parvocellular subdivision of the PVN. It has been demonstrated by previous studies that this part of the arcuate nucleus receives blood partly from the anterior pituitary through the subependymal plexus of the median eminence, and that it establishes, together with the median eminence, a blood-brain barrier-free area in the medial basal hypothalamus. Since the PVN-projecting NPY neurons in the arcuate neurons are sensitive to alterations in circulating corticosterone levels, the existence of a possible short feedback route in the stress-activated hypothalamo-pituitary-adrenocortical system is discussed.

Original languageEnglish
Title of host publicationStress, Neurotransmitters, and Hormones Neuroendocrine and Genetic Mechanisms
PublisherBlackwell Publishing Inc.
Pages57-63
Number of pages7
ISBN (Print)9781573316927
DOIs
Publication statusPublished - Dec 2008

Publication series

NameAnnals of the New York Academy of Sciences
Volume1148
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • Arcuate nucleus
  • Blood-brain barrier
  • Formalin stress
  • Fos-immunostaining
  • HPA axis
  • Neuropeptide Y

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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  • Cite this

    Palkovits, M. (2008). Stress-induced activation of neurons in the ventromedial arcuate nucleus: A blood-brain-CSF interface of the hypothalamus. In Stress, Neurotransmitters, and Hormones Neuroendocrine and Genetic Mechanisms (pp. 57-63). (Annals of the New York Academy of Sciences; Vol. 1148). Blackwell Publishing Inc.. https://doi.org/10.1196/annals.1410.062