Stress echo in chest pain unit: The SPEED trial

Gigliola Bedetti, Emilio M. Pasanisi, Giancarlo Tintori, Lucas Fonseca, Simone Tresoldi, Calogero Minneci, Z. Jambrik, Bruno Ghelarducci, Andres Orlandini, Eugenio Picano

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Background: Emergency room (ER) evaluation of patients with acute chest pain and non-diagnostic electrocardiography (ECG) remains a frequent and difficult problem. Aim: To assess safety and prognostic implications of pharmacological stress echocardiography in the ER chest pain unit (CPU). Methods: A total of 552 patients (321 males, age 58±12.6 years) with acute chest pain, negative serial enzymes and/or troponin, and ECG recordings, and normal/unchanged resting left ventricular function were prospectively enrolled and underwent pharmacological (dipyridamole or dobutamine) stress echo. Six echo labs that had passed the preliminary quality control for stress echo reading entered the study. Follow-up was obtained in all patients after a median period of 13 months. Results: No significant adverse events were observed during the test. Stress echocardiography was negative in 502 patients (91%) and positive in 50 (9%). The 502 patients with negative stress echocardiography were discharged with no or unchanged anti-ischemic medications. While the 50 patients with positive stress echo were admitted to the coronary care unit, 44 of these underwent coronary angiography with the result that 42 out of 44 showed significant coronary artery disease. There were 45 events in the follow-up: six in the 502 patients with negative and 39 in the 50 patients with positive stress echo (1.2% vs. 78%, p

Original languageEnglish
Pages (from-to)461-467
Number of pages7
JournalInternational Journal of Cardiology
Volume102
Issue number3
DOIs
Publication statusPublished - Jul 20 2005

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Chest Pain
Stress Echocardiography
Acute Pain
Hospital Emergency Service
Electrocardiography
Pharmacology
Coronary Care Units
Troponin
Dobutamine
Dipyridamole
Coronary Angiography
Left Ventricular Function
Quality Control
Reading
Coronary Artery Disease
Safety
Enzymes

Keywords

  • Chest pain
  • Emergency room
  • Prognosis
  • Stress echocardiography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Bedetti, G., Pasanisi, E. M., Tintori, G., Fonseca, L., Tresoldi, S., Minneci, C., ... Picano, E. (2005). Stress echo in chest pain unit: The SPEED trial. International Journal of Cardiology, 102(3), 461-467. https://doi.org/10.1016/j.ijcard.2004.05.058

Stress echo in chest pain unit : The SPEED trial. / Bedetti, Gigliola; Pasanisi, Emilio M.; Tintori, Giancarlo; Fonseca, Lucas; Tresoldi, Simone; Minneci, Calogero; Jambrik, Z.; Ghelarducci, Bruno; Orlandini, Andres; Picano, Eugenio.

In: International Journal of Cardiology, Vol. 102, No. 3, 20.07.2005, p. 461-467.

Research output: Contribution to journalArticle

Bedetti, G, Pasanisi, EM, Tintori, G, Fonseca, L, Tresoldi, S, Minneci, C, Jambrik, Z, Ghelarducci, B, Orlandini, A & Picano, E 2005, 'Stress echo in chest pain unit: The SPEED trial', International Journal of Cardiology, vol. 102, no. 3, pp. 461-467. https://doi.org/10.1016/j.ijcard.2004.05.058
Bedetti G, Pasanisi EM, Tintori G, Fonseca L, Tresoldi S, Minneci C et al. Stress echo in chest pain unit: The SPEED trial. International Journal of Cardiology. 2005 Jul 20;102(3):461-467. https://doi.org/10.1016/j.ijcard.2004.05.058
Bedetti, Gigliola ; Pasanisi, Emilio M. ; Tintori, Giancarlo ; Fonseca, Lucas ; Tresoldi, Simone ; Minneci, Calogero ; Jambrik, Z. ; Ghelarducci, Bruno ; Orlandini, Andres ; Picano, Eugenio. / Stress echo in chest pain unit : The SPEED trial. In: International Journal of Cardiology. 2005 ; Vol. 102, No. 3. pp. 461-467.
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