Streptokinase does not activate the complement system

J. Skopál, M. Vastag, L. Varga, K. Kolev, N. Szegedi, K. Mede, R. Machovich, Z. Nagy, J. Krámer

Research output: Contribution to journalArticle

Abstract

Streptokinase is an extensively used thrombolytic agent. However, different preparations cause severe hypotension during therapy, partially related to the complement cascade activation. In four ischaemic stroke patients treated with Streptase, an increased level of soluble terminal complement complex (SC5b-9) was measured. In the sera of normal subjects, the increase in SC5b-9 induced by Streptase, Kabikinase and Calbiochem streptokinases was highly significant (P <0.005). Sigma streptokinase did not activate the complement system. Sigma streptokinase analyzed by sodium dodecyl sulphate-polyacrylamide gel electrophoresis showed a homogeneous band. The other three preparations were contaminated with albumin and other proteins. Based on our in vivo and in vitro data, we conclude that complement activation is related to contamination of different streptokinase products rather than the streptokinase itself. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish
Pages (from-to)617-622
Number of pages6
JournalBlood Coagulation and Fibrinolysis
Volume11
Issue number7
DOIs
Publication statusPublished - 2000

Fingerprint

Streptokinase
Complement Activation
Complement Membrane Attack Complex
Fibrinolytic Agents
Sodium Dodecyl Sulfate
Hypotension
Polyacrylamide Gel Electrophoresis
Albumins
Stroke

Keywords

  • Complement activation
  • Streptokinase
  • Thrombolysis

ASJC Scopus subject areas

  • Hematology

Cite this

Streptokinase does not activate the complement system. / Skopál, J.; Vastag, M.; Varga, L.; Kolev, K.; Szegedi, N.; Mede, K.; Machovich, R.; Nagy, Z.; Krámer, J.

In: Blood Coagulation and Fibrinolysis, Vol. 11, No. 7, 2000, p. 617-622.

Research output: Contribution to journalArticle

Skopál, J. ; Vastag, M. ; Varga, L. ; Kolev, K. ; Szegedi, N. ; Mede, K. ; Machovich, R. ; Nagy, Z. ; Krámer, J. / Streptokinase does not activate the complement system. In: Blood Coagulation and Fibrinolysis. 2000 ; Vol. 11, No. 7. pp. 617-622.
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AU - Mede, K.

AU - Machovich, R.

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