Strategies to manage hepatitis C virus infection disease burden - Volume 3

F. Z. Alfaleh, N. Nugrahini, M. Matičič, I. Tolmane, M. Alzaabi, B. Hajarizadeh, J. Valantinas, D. Y. Kim, B. Hunyady, F. Abaalkhail, Z. Abbas, A. Abdou, A. Abourached, F. Al Braiki, F. Al Hosani, K. Al Jaberi, M. Al Khatry, M. A. Al Mulla, H. Al Quraishi, A. Al Rifai & 100 others Y. Al Serkal, A. Alam, H. I. Alashgar, S. M. Alavian, S. Alawadhi, L. Al-Dabal, P. Aldins, A. S. Alghamdi, R. Al-Hakeem, A. A. Aljumah, A. Almessabi, A. N. Alqutub, K. A. Alswat, I. Altraif, N. Andrea, A. M. Assiri, M. A. Babatin, A. Baqir, M. T. Barakat, O. M. Bergmann, A. R. Bizri, A. Chaudhry, M. S. Choi, T. Diab, S. Djauzi, E. S. El Hassan, S. El Khoury, C. Estes, S. Fakhry, J. I. Farooqi, H. Fridjonsdottir, R. A. Gani, A. Ghafoor Khan, L. Gheorghe, A. Goldis, M. Gottfredsson, S. Gregorcic, J. Gunter, S. Hamid, K. H. Han, I. Hasan, A. Hashim, G. Horvath, R. Husni, W. Jafri, A. Jeruma, J. G. Jonasson, B. Karlsdottir, Y. S. Kim, Z. Koutoubi, L. A. Lesmana, V. Liakina, Y. S. Lim, A. Löve, M. Maimets, M. Makara, R. Malekzadeh, M. S. Memon, S. Merat, J. E. Mokhbat, F. H. Mourad, D. H. Muljono, A. Nawaz, S. Olafsson, S. Priohutomo, H. Qureshi, P. Rassam, H. Razavi, D. Razavi-Shearer, K. Razavi-Shearer, B. Rozentale, M. Sadik, K. Saeed, A. Salamat, R. Salupere, F. M. Sanai, A. Sanityoso Sulaiman, R. A. Sayegh, J. D. Schmelzer, A. I. Sharara, A. Sibley, M. Siddiq, A. M. Siddiqui, G. Sigmundsdottir, B. Sigurdardottir, D. Speiciene, A. Sulaiman, M. A. Sultan, M. Taha, J. Tanaka, H. Tarifi, G. Tayyab, M. Ud Din, M. Umar, J. Videčnik-Zorman, C. Yaghi, E. Yunihastuti, M. A. Yusuf, B. F. Zuberi, S. Blach

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The hepatitis C virus (HCV) epidemic was forecasted through 2030 for 15 countries in Europe, the Middle East and Asia, and the relative impact of two scenarios was considered: increased treatment efficacy while holding the annual number of treated patients constant and increased treatment efficacy and an increased annual number of treated patients. Increasing levels of diagnosis and treatment, in combination with improved treatment efficacy, were critical for achieving substantial reductions in disease burden. A 90% reduction in total HCV infections within 15 years is feasible in most countries studied, but it required a coordinated effort to introduce harm reduction programmes to reduce new infections, screening to identify those already infected and treatment with high cure rate therapies. This suggests that increased capacity for screening and treatment will be critical in many countries. Birth cohort screening is a helpful tool for maximizing resources. Among European countries, the majority of patients were born between 1940 and 1985. A wider range of birth cohorts was seen in the Middle East and Asia (between 1925 and 1995).

Original languageEnglish
Pages (from-to)42-65
Number of pages24
JournalJournal of Viral Hepatitis
Volume22
DOIs
Publication statusPublished - Dec 1 2015

Fingerprint

Virus Diseases
Hepacivirus
Middle East
Far East
Parturition
Harm Reduction
Therapeutics
Infection

Keywords

  • diagnosis
  • disease burden
  • elimination
  • epidemiology
  • hepatitis C
  • hepatitis C virus
  • incidence
  • mortality
  • prevalence
  • scenarios
  • strategy
  • treatment

ASJC Scopus subject areas

  • Hepatology
  • Infectious Diseases
  • Virology

Cite this

Alfaleh, F. Z., Nugrahini, N., Matičič, M., Tolmane, I., Alzaabi, M., Hajarizadeh, B., ... Blach, S. (2015). Strategies to manage hepatitis C virus infection disease burden - Volume 3. Journal of Viral Hepatitis, 22, 42-65. https://doi.org/10.1111/jvh.12474

Strategies to manage hepatitis C virus infection disease burden - Volume 3. / Alfaleh, F. Z.; Nugrahini, N.; Matičič, M.; Tolmane, I.; Alzaabi, M.; Hajarizadeh, B.; Valantinas, J.; Kim, D. Y.; Hunyady, B.; Abaalkhail, F.; Abbas, Z.; Abdou, A.; Abourached, A.; Al Braiki, F.; Al Hosani, F.; Al Jaberi, K.; Al Khatry, M.; Al Mulla, M. A.; Al Quraishi, H.; Al Rifai, A.; Al Serkal, Y.; Alam, A.; Alashgar, H. I.; Alavian, S. M.; Alawadhi, S.; Al-Dabal, L.; Aldins, P.; Alghamdi, A. S.; Al-Hakeem, R.; Aljumah, A. A.; Almessabi, A.; Alqutub, A. N.; Alswat, K. A.; Altraif, I.; Andrea, N.; Assiri, A. M.; Babatin, M. A.; Baqir, A.; Barakat, M. T.; Bergmann, O. M.; Bizri, A. R.; Chaudhry, A.; Choi, M. S.; Diab, T.; Djauzi, S.; El Hassan, E. S.; El Khoury, S.; Estes, C.; Fakhry, S.; Farooqi, J. I.; Fridjonsdottir, H.; Gani, R. A.; Ghafoor Khan, A.; Gheorghe, L.; Goldis, A.; Gottfredsson, M.; Gregorcic, S.; Gunter, J.; Hamid, S.; Han, K. H.; Hasan, I.; Hashim, A.; Horvath, G.; Husni, R.; Jafri, W.; Jeruma, A.; Jonasson, J. G.; Karlsdottir, B.; Kim, Y. S.; Koutoubi, Z.; Lesmana, L. A.; Liakina, V.; Lim, Y. S.; Löve, A.; Maimets, M.; Makara, M.; Malekzadeh, R.; Memon, M. S.; Merat, S.; Mokhbat, J. E.; Mourad, F. H.; Muljono, D. H.; Nawaz, A.; Olafsson, S.; Priohutomo, S.; Qureshi, H.; Rassam, P.; Razavi, H.; Razavi-Shearer, D.; Razavi-Shearer, K.; Rozentale, B.; Sadik, M.; Saeed, K.; Salamat, A.; Salupere, R.; Sanai, F. M.; Sanityoso Sulaiman, A.; Sayegh, R. A.; Schmelzer, J. D.; Sharara, A. I.; Sibley, A.; Siddiq, M.; Siddiqui, A. M.; Sigmundsdottir, G.; Sigurdardottir, B.; Speiciene, D.; Sulaiman, A.; Sultan, M. A.; Taha, M.; Tanaka, J.; Tarifi, H.; Tayyab, G.; Ud Din, M.; Umar, M.; Videčnik-Zorman, J.; Yaghi, C.; Yunihastuti, E.; Yusuf, M. A.; Zuberi, B. F.; Blach, S.

In: Journal of Viral Hepatitis, Vol. 22, 01.12.2015, p. 42-65.

Research output: Contribution to journalArticle

Alfaleh, FZ, Nugrahini, N, Matičič, M, Tolmane, I, Alzaabi, M, Hajarizadeh, B, Valantinas, J, Kim, DY, Hunyady, B, Abaalkhail, F, Abbas, Z, Abdou, A, Abourached, A, Al Braiki, F, Al Hosani, F, Al Jaberi, K, Al Khatry, M, Al Mulla, MA, Al Quraishi, H, Al Rifai, A, Al Serkal, Y, Alam, A, Alashgar, HI, Alavian, SM, Alawadhi, S, Al-Dabal, L, Aldins, P, Alghamdi, AS, Al-Hakeem, R, Aljumah, AA, Almessabi, A, Alqutub, AN, Alswat, KA, Altraif, I, Andrea, N, Assiri, AM, Babatin, MA, Baqir, A, Barakat, MT, Bergmann, OM, Bizri, AR, Chaudhry, A, Choi, MS, Diab, T, Djauzi, S, El Hassan, ES, El Khoury, S, Estes, C, Fakhry, S, Farooqi, JI, Fridjonsdottir, H, Gani, RA, Ghafoor Khan, A, Gheorghe, L, Goldis, A, Gottfredsson, M, Gregorcic, S, Gunter, J, Hamid, S, Han, KH, Hasan, I, Hashim, A, Horvath, G, Husni, R, Jafri, W, Jeruma, A, Jonasson, JG, Karlsdottir, B, Kim, YS, Koutoubi, Z, Lesmana, LA, Liakina, V, Lim, YS, Löve, A, Maimets, M, Makara, M, Malekzadeh, R, Memon, MS, Merat, S, Mokhbat, JE, Mourad, FH, Muljono, DH, Nawaz, A, Olafsson, S, Priohutomo, S, Qureshi, H, Rassam, P, Razavi, H, Razavi-Shearer, D, Razavi-Shearer, K, Rozentale, B, Sadik, M, Saeed, K, Salamat, A, Salupere, R, Sanai, FM, Sanityoso Sulaiman, A, Sayegh, RA, Schmelzer, JD, Sharara, AI, Sibley, A, Siddiq, M, Siddiqui, AM, Sigmundsdottir, G, Sigurdardottir, B, Speiciene, D, Sulaiman, A, Sultan, MA, Taha, M, Tanaka, J, Tarifi, H, Tayyab, G, Ud Din, M, Umar, M, Videčnik-Zorman, J, Yaghi, C, Yunihastuti, E, Yusuf, MA, Zuberi, BF & Blach, S 2015, 'Strategies to manage hepatitis C virus infection disease burden - Volume 3', Journal of Viral Hepatitis, vol. 22, pp. 42-65. https://doi.org/10.1111/jvh.12474
Alfaleh FZ, Nugrahini N, Matičič M, Tolmane I, Alzaabi M, Hajarizadeh B et al. Strategies to manage hepatitis C virus infection disease burden - Volume 3. Journal of Viral Hepatitis. 2015 Dec 1;22:42-65. https://doi.org/10.1111/jvh.12474
Alfaleh, F. Z. ; Nugrahini, N. ; Matičič, M. ; Tolmane, I. ; Alzaabi, M. ; Hajarizadeh, B. ; Valantinas, J. ; Kim, D. Y. ; Hunyady, B. ; Abaalkhail, F. ; Abbas, Z. ; Abdou, A. ; Abourached, A. ; Al Braiki, F. ; Al Hosani, F. ; Al Jaberi, K. ; Al Khatry, M. ; Al Mulla, M. A. ; Al Quraishi, H. ; Al Rifai, A. ; Al Serkal, Y. ; Alam, A. ; Alashgar, H. I. ; Alavian, S. M. ; Alawadhi, S. ; Al-Dabal, L. ; Aldins, P. ; Alghamdi, A. S. ; Al-Hakeem, R. ; Aljumah, A. A. ; Almessabi, A. ; Alqutub, A. N. ; Alswat, K. A. ; Altraif, I. ; Andrea, N. ; Assiri, A. M. ; Babatin, M. A. ; Baqir, A. ; Barakat, M. T. ; Bergmann, O. M. ; Bizri, A. R. ; Chaudhry, A. ; Choi, M. S. ; Diab, T. ; Djauzi, S. ; El Hassan, E. S. ; El Khoury, S. ; Estes, C. ; Fakhry, S. ; Farooqi, J. I. ; Fridjonsdottir, H. ; Gani, R. A. ; Ghafoor Khan, A. ; Gheorghe, L. ; Goldis, A. ; Gottfredsson, M. ; Gregorcic, S. ; Gunter, J. ; Hamid, S. ; Han, K. H. ; Hasan, I. ; Hashim, A. ; Horvath, G. ; Husni, R. ; Jafri, W. ; Jeruma, A. ; Jonasson, J. G. ; Karlsdottir, B. ; Kim, Y. S. ; Koutoubi, Z. ; Lesmana, L. A. ; Liakina, V. ; Lim, Y. S. ; Löve, A. ; Maimets, M. ; Makara, M. ; Malekzadeh, R. ; Memon, M. S. ; Merat, S. ; Mokhbat, J. E. ; Mourad, F. H. ; Muljono, D. H. ; Nawaz, A. ; Olafsson, S. ; Priohutomo, S. ; Qureshi, H. ; Rassam, P. ; Razavi, H. ; Razavi-Shearer, D. ; Razavi-Shearer, K. ; Rozentale, B. ; Sadik, M. ; Saeed, K. ; Salamat, A. ; Salupere, R. ; Sanai, F. M. ; Sanityoso Sulaiman, A. ; Sayegh, R. A. ; Schmelzer, J. D. ; Sharara, A. I. ; Sibley, A. ; Siddiq, M. ; Siddiqui, A. M. ; Sigmundsdottir, G. ; Sigurdardottir, B. ; Speiciene, D. ; Sulaiman, A. ; Sultan, M. A. ; Taha, M. ; Tanaka, J. ; Tarifi, H. ; Tayyab, G. ; Ud Din, M. ; Umar, M. ; Videčnik-Zorman, J. ; Yaghi, C. ; Yunihastuti, E. ; Yusuf, M. A. ; Zuberi, B. F. ; Blach, S. / Strategies to manage hepatitis C virus infection disease burden - Volume 3. In: Journal of Viral Hepatitis. 2015 ; Vol. 22. pp. 42-65.
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TY - JOUR

T1 - Strategies to manage hepatitis C virus infection disease burden - Volume 3

AU - Alfaleh, F. Z.

AU - Nugrahini, N.

AU - Matičič, M.

AU - Tolmane, I.

AU - Alzaabi, M.

AU - Hajarizadeh, B.

AU - Valantinas, J.

AU - Kim, D. Y.

AU - Hunyady, B.

AU - Abaalkhail, F.

AU - Abbas, Z.

AU - Abdou, A.

AU - Abourached, A.

AU - Al Braiki, F.

AU - Al Hosani, F.

AU - Al Jaberi, K.

AU - Al Khatry, M.

AU - Al Mulla, M. A.

AU - Al Quraishi, H.

AU - Al Rifai, A.

AU - Al Serkal, Y.

AU - Alam, A.

AU - Alashgar, H. I.

AU - Alavian, S. M.

AU - Alawadhi, S.

AU - Al-Dabal, L.

AU - Aldins, P.

AU - Alghamdi, A. S.

AU - Al-Hakeem, R.

AU - Aljumah, A. A.

AU - Almessabi, A.

AU - Alqutub, A. N.

AU - Alswat, K. A.

AU - Altraif, I.

AU - Andrea, N.

AU - Assiri, A. M.

AU - Babatin, M. A.

AU - Baqir, A.

AU - Barakat, M. T.

AU - Bergmann, O. M.

AU - Bizri, A. R.

AU - Chaudhry, A.

AU - Choi, M. S.

AU - Diab, T.

AU - Djauzi, S.

AU - El Hassan, E. S.

AU - El Khoury, S.

AU - Estes, C.

AU - Fakhry, S.

AU - Farooqi, J. I.

AU - Fridjonsdottir, H.

AU - Gani, R. A.

AU - Ghafoor Khan, A.

AU - Gheorghe, L.

AU - Goldis, A.

AU - Gottfredsson, M.

AU - Gregorcic, S.

AU - Gunter, J.

AU - Hamid, S.

AU - Han, K. H.

AU - Hasan, I.

AU - Hashim, A.

AU - Horvath, G.

AU - Husni, R.

AU - Jafri, W.

AU - Jeruma, A.

AU - Jonasson, J. G.

AU - Karlsdottir, B.

AU - Kim, Y. S.

AU - Koutoubi, Z.

AU - Lesmana, L. A.

AU - Liakina, V.

AU - Lim, Y. S.

AU - Löve, A.

AU - Maimets, M.

AU - Makara, M.

AU - Malekzadeh, R.

AU - Memon, M. S.

AU - Merat, S.

AU - Mokhbat, J. E.

AU - Mourad, F. H.

AU - Muljono, D. H.

AU - Nawaz, A.

AU - Olafsson, S.

AU - Priohutomo, S.

AU - Qureshi, H.

AU - Rassam, P.

AU - Razavi, H.

AU - Razavi-Shearer, D.

AU - Razavi-Shearer, K.

AU - Rozentale, B.

AU - Sadik, M.

AU - Saeed, K.

AU - Salamat, A.

AU - Salupere, R.

AU - Sanai, F. M.

AU - Sanityoso Sulaiman, A.

AU - Sayegh, R. A.

AU - Schmelzer, J. D.

AU - Sharara, A. I.

AU - Sibley, A.

AU - Siddiq, M.

AU - Siddiqui, A. M.

AU - Sigmundsdottir, G.

AU - Sigurdardottir, B.

AU - Speiciene, D.

AU - Sulaiman, A.

AU - Sultan, M. A.

AU - Taha, M.

AU - Tanaka, J.

AU - Tarifi, H.

AU - Tayyab, G.

AU - Ud Din, M.

AU - Umar, M.

AU - Videčnik-Zorman, J.

AU - Yaghi, C.

AU - Yunihastuti, E.

AU - Yusuf, M. A.

AU - Zuberi, B. F.

AU - Blach, S.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - The hepatitis C virus (HCV) epidemic was forecasted through 2030 for 15 countries in Europe, the Middle East and Asia, and the relative impact of two scenarios was considered: increased treatment efficacy while holding the annual number of treated patients constant and increased treatment efficacy and an increased annual number of treated patients. Increasing levels of diagnosis and treatment, in combination with improved treatment efficacy, were critical for achieving substantial reductions in disease burden. A 90% reduction in total HCV infections within 15 years is feasible in most countries studied, but it required a coordinated effort to introduce harm reduction programmes to reduce new infections, screening to identify those already infected and treatment with high cure rate therapies. This suggests that increased capacity for screening and treatment will be critical in many countries. Birth cohort screening is a helpful tool for maximizing resources. Among European countries, the majority of patients were born between 1940 and 1985. A wider range of birth cohorts was seen in the Middle East and Asia (between 1925 and 1995).

AB - The hepatitis C virus (HCV) epidemic was forecasted through 2030 for 15 countries in Europe, the Middle East and Asia, and the relative impact of two scenarios was considered: increased treatment efficacy while holding the annual number of treated patients constant and increased treatment efficacy and an increased annual number of treated patients. Increasing levels of diagnosis and treatment, in combination with improved treatment efficacy, were critical for achieving substantial reductions in disease burden. A 90% reduction in total HCV infections within 15 years is feasible in most countries studied, but it required a coordinated effort to introduce harm reduction programmes to reduce new infections, screening to identify those already infected and treatment with high cure rate therapies. This suggests that increased capacity for screening and treatment will be critical in many countries. Birth cohort screening is a helpful tool for maximizing resources. Among European countries, the majority of patients were born between 1940 and 1985. A wider range of birth cohorts was seen in the Middle East and Asia (between 1925 and 1995).

KW - diagnosis

KW - disease burden

KW - elimination

KW - epidemiology

KW - hepatitis C

KW - hepatitis C virus

KW - incidence

KW - mortality

KW - prevalence

KW - scenarios

KW - strategy

KW - treatment

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UR - http://www.scopus.com/inward/citedby.url?scp=84945372576&partnerID=8YFLogxK

U2 - 10.1111/jvh.12474

DO - 10.1111/jvh.12474

M3 - Article

VL - 22

SP - 42

EP - 65

JO - Journal of Viral Hepatitis

JF - Journal of Viral Hepatitis

SN - 1352-0504

ER -