Strategies in optical resolution: a practical guide

Ferenc Faigl, Elemér Fogassy, Mihály Nógrádi, Emese Pálovics, József Schindler

Research output: Contribution to journalReview article

100 Citations (Scopus)

Abstract

Despite the dramatic development of enantioselective synthesis and chromatographic separation methods, resolution still remains the most inexpensive and operationally simplest method for producing pure enantiomers on a large scale. No extreme conditions or expensive reagents are required and the expensive resolving agents can be eventually recovered. This review presents guidelines for selecting the optimal method for resolving a given racemate and is based mainly on the authors long experience in the resolution of industrially important molecules. Methods for predicting the efficiency of the resolution based on the analysis of physico-chemical properties of the reactants are also described.

Original languageEnglish
Pages (from-to)519-536
Number of pages18
JournalTetrahedron Asymmetry
Volume19
Issue number5
DOIs
Publication statusPublished - Mar 18 2008

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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