Strategic infarcts of the thalamus in vascular dementia

I. Szirmai, Ildikó Vastagh, Éva Szombathelyi, A. Kamondi

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Strategic infarcts or focal hemorrhages involving the paramedian nuclei of the thalamus may alter consciousness and produce complex neuropsychological symptoms such as impairment of memory, attention and motivation. Lesions disrupting the thalamo-prefrontal circuits lead to severe subcortical dementia. We analysed here the clinical, neuropsychological and neuroimaging data of 19 patients with cerebrovascular lesions in the thalamus. In six patients with bilateral paramedian infarcts, and in two with anterior thalamic infarcts, vascular dementia and severe personality changes developed. SPECT findings did not correlate with the neuropsychological symptoms. Transcortical sensory and motor aphasia was observed in four patients with thalamic hemorrhages and infarcts. In these patients SPECT detected hypoperfusion in adjacent cortical areas. Clinical symptoms and outcome of four patients are reported in detail. The clinico-morphological correlations of the thalamo-cortical circuits are reviewed and the possible causes of multiple cognitive and behavioural consequences of vascular thalamic lesions are discussed.

Original languageEnglish
Pages (from-to)91-97
Number of pages7
JournalJournal of the Neurological Sciences
Volume203-204
DOIs
Publication statusPublished - Nov 15 2002

Fingerprint

Vascular Dementia
Thalamus
Single-Photon Emission-Computed Tomography
Wernicke Aphasia
Broca Aphasia
Hemorrhage
Consciousness
Neuroimaging
Blood Vessels
Personality
Dementia
Motivation

Keywords

  • Aphasia
  • Dementia
  • Infarct
  • Subcortical vascular dementia
  • Thalamus

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Developmental Neuroscience
  • Neurology
  • Neuroscience(all)

Cite this

Strategic infarcts of the thalamus in vascular dementia. / Szirmai, I.; Vastagh, Ildikó; Szombathelyi, Éva; Kamondi, A.

In: Journal of the Neurological Sciences, Vol. 203-204, 15.11.2002, p. 91-97.

Research output: Contribution to journalArticle

Szirmai, I. ; Vastagh, Ildikó ; Szombathelyi, Éva ; Kamondi, A. / Strategic infarcts of the thalamus in vascular dementia. In: Journal of the Neurological Sciences. 2002 ; Vol. 203-204. pp. 91-97.
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