Strain and strain rate by speckle-tracking echocardiography correlate with pressure-volume loop-derived contractility indices in a rat model of athlete’s heart

Attila Kovács, Attila Oláh, Árpád Lux, Csaba Mátyás, Balázs Tamás Németh, Dalma Kellermayer, Mihály Ruppert, Marianna Török, Lilla Szabó, Anna Meltzer, Alexandra Assabiny, Ede Birtalan, Béla Merkely, Tamás Radovits

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Contractile function is considered to be precisely measurable only by invasive hemodynamics. We aimed to correlate strain values measured by speckle-tracking echocardiography (STE) with sensitive contractility parameters of pressure-volume (P-V) analysis in a rat model of exercise-induced left ventricular (LV) hypertrophy. LV hypertrophy was induced in rats by swim training and was compared with untrained controls. Echocardiography was performed using a 13-MHz linear transducer to obtain LV long-and short-axis recordings for STE analysis (GE EchoPAC). Global longitudinal (GLS) and circumferential strain (GCS) and longitudinal (LSr) and circumferential systolic strain rate (CSr) were measured. LV P-V analysis was performed using a pressure-conductance microcatheter, and load-independent contractility indices [slope of the end-systolic P-V relationship (ESPVR), preload recruitable stroke work (PRSW), and maximal dP/dt-enddiastolic volume relationship (dP/dtmax-EDV)] were calculated. Trained rats had increased LV mass index (trained vs. control; 2.76±0.07 vs. 2.14±0.05 g/kg, P<0.001). P-V loop-derived contractility parameters were significantly improved in the trained group (ESPVR: 3.58±0.22 vs. 2.51±0.11 mmHg/μl; PRSW: 131±4 vs. 104±2 mmHg, P<0.01). Strain and strain rate parameters were also supernormal in trained rats (GLS:-18.8±0.3 vs.-15.8±0.4%; LSr:-5.0±0.2 vs.-4.1±0.1 Hz; GCS:-18.9±0.8 vs.-14.9±0.6%; CSr:-4.9±0.2 vs.-3.8±0.2 Hz, P<0.01). ESPVR correlated with GLS (r=-0.71) and LSr (r=-0.53) and robustly with GCS (r=-0.83) and CSr (r=-0.75, all P<0.05). PRSW was strongly related to GLS (r=-0.64) and LSr (r=-0.71, both P<0.01). STE can be a feasible and useful method for animal experiments. In our rat model, strain and strain rate parameters closely reflected the improvement in intrinsic contractile function induced by exercise training.

Original languageEnglish
Pages (from-to)743-748
Number of pages6
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume308
Issue number7
DOIs
Publication statusPublished - Jan 1 2015

Keywords

  • Athlete’s heart
  • Contractility
  • Pressure-volume analysis
  • Speckle-tracking echocardiography
  • Strain

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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