Stochastic theory of multiple-site linear adsorption chromatography

Alberto Cavazzini, Maurizio Remelli, Francesco Dondi, A. Felinger

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

The problem of multiple-site adsorption chromatography is connected with a great number of questions of both chromatographic nature (e.g., the effects of surface heterogeneity on the column efficiency and on the peak shape parameters) and physical chemical relevance (e.g., the study of residence time in one sorption step on heterogeneous surfaces). In this study, the multiple-site adsorption, under linear conditions, is considered by using the molecular dynamic theory of chromatography. The probabilistic description is made by means of the characteristic function method and the solution is obtained under the most general conditions of surface heterogeneity. Different cases of surface energy distribution are considered. Relevant chromatographic attributes and the peak shape parameters-skew and excess-are investigated for heterogeneous stationary-phase surfaces. The chromatograms show that slow kinetics and surface heterogeneity have momentous impact on peak tailing. The equivalence of the stochastic model and the lumped kinetic model is demonstrated.

Original languageEnglish
Pages (from-to)3453-3462
Number of pages10
JournalAnalytical Chemistry
Volume71
Issue number16
DOIs
Publication statusPublished - Aug 15 1999

Fingerprint

Chromatography
Adsorption
Kinetics
Tailings
Stochastic models
Interfacial energy
Molecular dynamics
Sorption

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Stochastic theory of multiple-site linear adsorption chromatography. / Cavazzini, Alberto; Remelli, Maurizio; Dondi, Francesco; Felinger, A.

In: Analytical Chemistry, Vol. 71, No. 16, 15.08.1999, p. 3453-3462.

Research output: Contribution to journalArticle

Cavazzini, Alberto ; Remelli, Maurizio ; Dondi, Francesco ; Felinger, A. / Stochastic theory of multiple-site linear adsorption chromatography. In: Analytical Chemistry. 1999 ; Vol. 71, No. 16. pp. 3453-3462.
@article{88f0d2bf85764925a7cae8d992b9ee94,
title = "Stochastic theory of multiple-site linear adsorption chromatography",
abstract = "The problem of multiple-site adsorption chromatography is connected with a great number of questions of both chromatographic nature (e.g., the effects of surface heterogeneity on the column efficiency and on the peak shape parameters) and physical chemical relevance (e.g., the study of residence time in one sorption step on heterogeneous surfaces). In this study, the multiple-site adsorption, under linear conditions, is considered by using the molecular dynamic theory of chromatography. The probabilistic description is made by means of the characteristic function method and the solution is obtained under the most general conditions of surface heterogeneity. Different cases of surface energy distribution are considered. Relevant chromatographic attributes and the peak shape parameters-skew and excess-are investigated for heterogeneous stationary-phase surfaces. The chromatograms show that slow kinetics and surface heterogeneity have momentous impact on peak tailing. The equivalence of the stochastic model and the lumped kinetic model is demonstrated.",
author = "Alberto Cavazzini and Maurizio Remelli and Francesco Dondi and A. Felinger",
year = "1999",
month = "8",
day = "15",
doi = "10.1021/ac990282p",
language = "English",
volume = "71",
pages = "3453--3462",
journal = "Analytical Chemistry",
issn = "0003-2700",
publisher = "American Chemical Society",
number = "16",

}

TY - JOUR

T1 - Stochastic theory of multiple-site linear adsorption chromatography

AU - Cavazzini, Alberto

AU - Remelli, Maurizio

AU - Dondi, Francesco

AU - Felinger, A.

PY - 1999/8/15

Y1 - 1999/8/15

N2 - The problem of multiple-site adsorption chromatography is connected with a great number of questions of both chromatographic nature (e.g., the effects of surface heterogeneity on the column efficiency and on the peak shape parameters) and physical chemical relevance (e.g., the study of residence time in one sorption step on heterogeneous surfaces). In this study, the multiple-site adsorption, under linear conditions, is considered by using the molecular dynamic theory of chromatography. The probabilistic description is made by means of the characteristic function method and the solution is obtained under the most general conditions of surface heterogeneity. Different cases of surface energy distribution are considered. Relevant chromatographic attributes and the peak shape parameters-skew and excess-are investigated for heterogeneous stationary-phase surfaces. The chromatograms show that slow kinetics and surface heterogeneity have momentous impact on peak tailing. The equivalence of the stochastic model and the lumped kinetic model is demonstrated.

AB - The problem of multiple-site adsorption chromatography is connected with a great number of questions of both chromatographic nature (e.g., the effects of surface heterogeneity on the column efficiency and on the peak shape parameters) and physical chemical relevance (e.g., the study of residence time in one sorption step on heterogeneous surfaces). In this study, the multiple-site adsorption, under linear conditions, is considered by using the molecular dynamic theory of chromatography. The probabilistic description is made by means of the characteristic function method and the solution is obtained under the most general conditions of surface heterogeneity. Different cases of surface energy distribution are considered. Relevant chromatographic attributes and the peak shape parameters-skew and excess-are investigated for heterogeneous stationary-phase surfaces. The chromatograms show that slow kinetics and surface heterogeneity have momentous impact on peak tailing. The equivalence of the stochastic model and the lumped kinetic model is demonstrated.

UR - http://www.scopus.com/inward/record.url?scp=0033566590&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033566590&partnerID=8YFLogxK

U2 - 10.1021/ac990282p

DO - 10.1021/ac990282p

M3 - Article

AN - SCOPUS:0033566590

VL - 71

SP - 3453

EP - 3462

JO - Analytical Chemistry

JF - Analytical Chemistry

SN - 0003-2700

IS - 16

ER -