Stochastic kinetics of the circular gene hypothesis: Feedback effects and protein fluctuations

R. R. Wadhwa, L. Zalányi, J. Szente, L. Négyessy, P. Érdi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Stochastic kinetic models of genetic expression are able to describe protein fluctuations. A comparative study of the canonical and a feedback model is given here by using stochastic simulation methods. The feedback model is a skeleton model implementation of the circular gene hypothesis, which suggests the interaction between the synthesis and degradation of mRNA. Qualitative and quantitative changes in the shape and in the numerical characteristics of the stationary distributions suggest that more combined experimental and theoretical studies should be done to uncover the details of the kinetic mechanisms of gene expressions.

Original languageEnglish
Pages (from-to)326-336
Number of pages11
JournalMathematics and Computers in Simulation
Volume133
DOIs
Publication statusPublished - Mar 1 2017

Keywords

  • Feedback
  • Genetic expression
  • Protein fluctuation
  • Stochastic kinetics

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)
  • Numerical Analysis
  • Modelling and Simulation
  • Applied Mathematics

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