Stochastic kinetics of the circular gene hypothesis: Feedback effects and protein fluctuations

R. R. Wadhwa, L. Zalányi, J. Szente, L. Négyessy, P. Érdi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Stochastic kinetic models of genetic expression are able to describe protein fluctuations. A comparative study of the canonical and a feedback model is given here by using stochastic simulation methods. The feedback model is a skeleton model implementation of the circular gene hypothesis, which suggests the interaction between the synthesis and degradation of mRNA. Qualitative and quantitative changes in the shape and in the numerical characteristics of the stationary distributions suggest that more combined experimental and theoretical studies should be done to uncover the details of the kinetic mechanisms of gene expressions.

Original languageEnglish
JournalMathematics and Computers in Simulation
DOIs
Publication statusAccepted/In press - Jan 23 2015

Fingerprint

Genes
Kinetics
Fluctuations
Gene
Proteins
Protein
Feedback
Stochastic Simulation
Stochastic Methods
Kinetic Model
Stationary Distribution
Skeleton
Simulation Methods
Messenger RNA
Gene Expression
Comparative Study
Stochastic Model
Degradation
Gene expression
Model

Keywords

  • Feedback
  • Genetic expression
  • Protein fluctuation
  • Stochastic kinetics

ASJC Scopus subject areas

  • Modelling and Simulation
  • Numerical Analysis
  • Applied Mathematics
  • Theoretical Computer Science
  • Computer Science(all)

Cite this

Stochastic kinetics of the circular gene hypothesis : Feedback effects and protein fluctuations. / Wadhwa, R. R.; Zalányi, L.; Szente, J.; Négyessy, L.; Érdi, P.

In: Mathematics and Computers in Simulation, 23.01.2015.

Research output: Contribution to journalArticle

@article{266a282daab14d93a9a788305cb4b4f5,
title = "Stochastic kinetics of the circular gene hypothesis: Feedback effects and protein fluctuations",
abstract = "Stochastic kinetic models of genetic expression are able to describe protein fluctuations. A comparative study of the canonical and a feedback model is given here by using stochastic simulation methods. The feedback model is a skeleton model implementation of the circular gene hypothesis, which suggests the interaction between the synthesis and degradation of mRNA. Qualitative and quantitative changes in the shape and in the numerical characteristics of the stationary distributions suggest that more combined experimental and theoretical studies should be done to uncover the details of the kinetic mechanisms of gene expressions.",
keywords = "Feedback, Genetic expression, Protein fluctuation, Stochastic kinetics",
author = "Wadhwa, {R. R.} and L. Zal{\'a}nyi and J. Szente and L. N{\'e}gyessy and P. {\'E}rdi",
year = "2015",
month = "1",
day = "23",
doi = "10.1016/j.matcom.2015.08.006",
language = "English",
journal = "Mathematics and Computers in Simulation",
issn = "0378-4754",
publisher = "Elsevier",

}

TY - JOUR

T1 - Stochastic kinetics of the circular gene hypothesis

T2 - Feedback effects and protein fluctuations

AU - Wadhwa, R. R.

AU - Zalányi, L.

AU - Szente, J.

AU - Négyessy, L.

AU - Érdi, P.

PY - 2015/1/23

Y1 - 2015/1/23

N2 - Stochastic kinetic models of genetic expression are able to describe protein fluctuations. A comparative study of the canonical and a feedback model is given here by using stochastic simulation methods. The feedback model is a skeleton model implementation of the circular gene hypothesis, which suggests the interaction between the synthesis and degradation of mRNA. Qualitative and quantitative changes in the shape and in the numerical characteristics of the stationary distributions suggest that more combined experimental and theoretical studies should be done to uncover the details of the kinetic mechanisms of gene expressions.

AB - Stochastic kinetic models of genetic expression are able to describe protein fluctuations. A comparative study of the canonical and a feedback model is given here by using stochastic simulation methods. The feedback model is a skeleton model implementation of the circular gene hypothesis, which suggests the interaction between the synthesis and degradation of mRNA. Qualitative and quantitative changes in the shape and in the numerical characteristics of the stationary distributions suggest that more combined experimental and theoretical studies should be done to uncover the details of the kinetic mechanisms of gene expressions.

KW - Feedback

KW - Genetic expression

KW - Protein fluctuation

KW - Stochastic kinetics

UR - http://www.scopus.com/inward/record.url?scp=84940703765&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84940703765&partnerID=8YFLogxK

U2 - 10.1016/j.matcom.2015.08.006

DO - 10.1016/j.matcom.2015.08.006

M3 - Article

AN - SCOPUS:84940703765

JO - Mathematics and Computers in Simulation

JF - Mathematics and Computers in Simulation

SN - 0378-4754

ER -