Stochastic and deterministic dynamics of intrinsically irregular firing in cortical inhibitory interneurons

Philipe R.F. Mendonça, Mariana Vargas-Caballero, Ferenc Erdélyi, Gábor Szabó, Ole Paulsen, Hugh P.C. Robinson

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Most cortical neurons fire regularly when excited by a constant stimulus. In contrast, irregular-spiking (IS) interneurons are remarkable for the intrinsic variability of their spike timing, which can synchronize amongst IS cells via specific gap junctions. Here, we have studied the biophysical mechanisms of this irregular spiking in mice, and how IS cells fire in the context of synchronous network oscillations. Using patch-clamp recordings, artificial dynamic conductance injection, pharmacological analysis and computational modeling, we show that spike time irregularity is generated by a nonlinear dynamical interaction of voltage-dependent sodium and fast-inactivating potassium channels just below spike threshold, amplifying channel noise. This active irregularity may help IS cells synchronize with each other at gamma range frequencies, while resisting synchronization to lower input frequencies.

Original languageEnglish
Article numbere16475
JournaleLife
Volume5
Issue numberAUGUST
DOIs
Publication statusPublished - Aug 18 2016

ASJC Scopus subject areas

  • Neuroscience(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Stochastic and deterministic dynamics of intrinsically irregular firing in cortical inhibitory interneurons'. Together they form a unique fingerprint.

  • Cite this

    Mendonça, P. R. F., Vargas-Caballero, M., Erdélyi, F., Szabó, G., Paulsen, O., & Robinson, H. P. C. (2016). Stochastic and deterministic dynamics of intrinsically irregular firing in cortical inhibitory interneurons. eLife, 5(AUGUST), [e16475]. https://doi.org/10.7554/eLife.16475