Stimulus-secretion coupling in angiotensin-stimulated adrenal glomerulosa cells

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Adrenal glomerulosa cell is a suitable model for a comparative study of signal transducing mechanisms since its secretory activity is regulated by at least three different mechanisms: the adenylate cyclase-cAMP system (for ACTH), the voltage-dependent Ca2+ channel (for K+ and perhaps for angiotensin II) and the inositol 1,4,5-trisphosphate-Ca2+ system (for angiotensin II and vasopressin). The role of inositol phosphates, extracellular Ca2+ and protein kinase C in the induction and sustaining of aldosterone production* * According to the general vie, since aldosterone is not stored in the cells, the control of secretion (release) and that of production are identical. by cells exposed to angiotensin II is critically reviewed.

Original languageEnglish
Pages (from-to)443-453
Number of pages11
JournalJournal of Steroid Biochemistry
Issue number4
Publication statusPublished - Apr 1988

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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