Lymphokines, the biological active products of lymphoid cells responding to antigen or mitogens (e.g. concanavalin A, phytohaemagglutinin) are considered potential mediators of cellular immunity. Their role manifests itself with a delayed type hypersensitivity reaction, in protective immunity and in cell cooperation effects. Beside the macrophage migration inhibitory factor there are other biologically active products of lymphocytes affecting the macrophages, such as macrophage chemotactin, a substance attracting macrophages and the macrophage activation factor which enhances macrophages motility and phagocytosis. Fowler et al. demonstrated the enhancement of macrophage bacteriostasis by the products of activated lymphocytes. Pantalone and Page described the lymphokine-induced production and release of lysosomal enzymes by macrophages. According to previous data lymphokines can be regarded as macrophage activators. The role of the lymphokine factor, neutrophil chemotactin, has been shown in the processes of lymphocyte-neutrophil interactions, but there is hardly any information whether lymphokines can increase the phagocytosis of neutrophils. To obtain direct evidence of the effect of the lymphokine containing supernatants of concanavalin A stimulated human lymphocytes on the phagocyting and intracellular killing activities of human macrophages and neutrophils, the authors examined the particles of Saccharomyces cerevisiae phagocyted by these cells.
|Number of pages||3|
|Journal||Acta microbiologica Academiae Scientiarum Hungaricae|
|Publication status||Published - Dec 1 1978|
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