Stimulation of capsaicin-sensitive sensory peripheral nerves with topically applied resiniferatoxin decreases salicylate-induced gastric H+ back-diffusion in the rat

O. M.E. Abdel-Salam, B. Bódis, O. Karádi, L. Nagy, J. Szolcsányi, G. Mózsik

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Abstract

Capsaicin-sensitive sensory nerves (CSSN) exert local protective functions in the stomach and have been proposed to regulate gastric H+ back-diffusion. The present study aimed to evaluate the possible influence of stimulation of CSSN with the intragastrically (ig) applied capsaicin analogue, resiniferatoxin (RTX), on gastric H+ back-diffusion and mucosal injury caused by ig application of HCl (2 ml 0.15 mol/L) or acidified salicylate (200 mg/kg in 2 ml 0.15 mol/L HCl) after 1 or 2 h in the pylorus-ligated rat. Stimulation of CSSN with a low concentration (0.04 μg/ml) of RTX markedly decreased H+ back-diffusion caused by acidified salicylate. After acute bilateral truncal vagotomy or treatment with atropine sulphate, RTX did not inhibit gastric acid back-diffusion. Surgical vagotomy alone increased, while RTX or atropine markedly diminished, the development of gastric mucosal injury in these models. In saline-treated rats, RTX significantly reduced gastric secretory volume and acid output. The inhibitory effect lasted for 1 h. These data suggest an essential role for CSSN in regulation of gastric acid secretion and in maintaining the integrity of the gastric mucosa that appear to depend on intact vagal nerves.

Original languageEnglish
Pages (from-to)121-133
Number of pages13
JournalInflammoPharmacology
Volume3
Issue number2
DOIs
Publication statusPublished - Jun 1 1995

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Keywords

  • H back-diffusion
  • capsaicin-sensitive sensory nerves
  • gastric acid
  • resiniferatoxin
  • salicylate

ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Pharmacology (medical)

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