Stimulation of 5-HT1A and 5-HT2/5-HT1C receptors induce oxytocin release in the male rat

Gyorgy Bagdy, Konstantine T. Kalogeras

Research output: Contribution to journalArticle

68 Citations (Scopus)


Plasma oxytocin responses to the 5-HT1A receptor agonists 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), buspirone and ipsapirone, and the 5-HT2/5-HT1C receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)2-aminopropane (DOI) have been studied in conscious, freely moving male rats. All four compounds caused dose-related increases in plasma oxytocin concentrations after intravenous administration. Oxytocin responses to 8-OH-DPAT were significantly attenuated by pretreatment with the 5-HT1A receptor antagonist NAN-190 while responses to DOI were blocked by pretreatment with the 5-HT2/5-HT1C receptor antagonist ritanserin. Since vasopressin concentration did not change despite the marked elevation in plasma oxytocin, these results suggest that 5-HT1A and 5-HT2/5-HT1C receptors all stimulate oxytocin secretion, and this effect does not reflect a general neurohypophyseal hormone release.

Original languageEnglish
Pages (from-to)330-332
Number of pages3
JournalBrain research
Issue number2
Publication statusPublished - May 21 1993


  • 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin)
  • Buspirone
  • DOI (1-(2,5-dimethoxy-4-iodophenyl)2-aminopropane)
  • Ipsapirone
  • Male rat
  • NAN-190
  • Oxytocin
  • Ritanserin
  • Serotonin 5-HT receptor
  • Serotonin 5-HT receptor
  • Serotonin 5-HT receptor
  • Vasopressin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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