The effects in vitro and in vivo of triiodothyronine on certain functions of human lymphocytes and polymorphonuclear granulocytes have been investigated. Triiodothyronine was able to enhance the phagocytic capacity and chemiluminescent activity of polymorphonuclear granulocytes. PHA-P-induced3H-thymidine incorporation into lymphocytes was significantly increased in the presence of triiodothyronine. A concentration-dependent enhancing effect of triiodothyronine on antibody-dependent enhancing effect of triiodothyronine on antibody-dependent cell-mediated cytotoxicity was also observed.
- Graves' disease
- antibody-dependent cell-mediated cytotoxicity
- lymphocyte transformation
ASJC Scopus subject areas
- Pharmacology (medical)