Steroids, XL. 15‐(hydroxymethyl)androstene and ‐estratriene derivatives

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Abstract

15α‐Hydroxymethyl‐5‐androstene‐3β,16β,17β‐triol (5d) and 16β‐hydroxy‐15α‐(hydroxymethyl)estratriene derivatives 9 were prepared from the corresponding 15‐hydroxymethylene‐16‐ketones 3 and 4. The configurations of the chiral centers were determined by means of chemical transformations and on the basis of spectroscopic data. The D‐seco derivatives 6 and 8 were identified as the products of a fragmentation and a 1,3‐dicarbonyl fission, respectively.

Original languageEnglish
Pages (from-to)973-978
Number of pages6
JournalLiebigs Annalen der Chemie
Volume1988
Issue number10
DOIs
Publication statusPublished - 1988

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Androstenes
steroids
fission
fragmentation
Steroids
Derivatives
products
configurations

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Steroids, XL. 15‐(hydroxymethyl)androstene and ‐estratriene derivatives. / Vincze, Irén; Somlai, C.; Schneider, G.; Dombi, G.

In: Liebigs Annalen der Chemie, Vol. 1988, No. 10, 1988, p. 973-978.

Research output: Contribution to journalArticle

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AU - Vincze, Irén

AU - Somlai, C.

AU - Schneider, G.

AU - Dombi, G.

PY - 1988

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AB - 15α‐Hydroxymethyl‐5‐androstene‐3β,16β,17β‐triol (5d) and 16β‐hydroxy‐15α‐(hydroxymethyl)estratriene derivatives 9 were prepared from the corresponding 15‐hydroxymethylene‐16‐ketones 3 and 4. The configurations of the chiral centers were determined by means of chemical transformations and on the basis of spectroscopic data. The D‐seco derivatives 6 and 8 were identified as the products of a fragmentation and a 1,3‐dicarbonyl fission, respectively.

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