Thermolysis of the four possible isomeric 3-methoxy-16-methylestra-1,3, 5(10)-trien-17-yl azidoformates 1b, 6b, 10b and 14b, of 3-methoxyestra-1,3,5(10) -trien-17β-yl azidoformate 17b, and of 16β-azidoformyloxymethyl-3- methoxyestra-1,3,5(10)-triene 21b was realized at 100°C. Thermolysis results in insertion of the nitrene intermediate into C-H bonds, the site of which depends on the steric position of the substituents in the D ring of the sterane skeleton.
|Number of pages||6|
|Journal||Journal of the Chemical Society, Perkin Transactions 1|
|Publication status||Published - Dec 1 1991|
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