Steroid levels in the serum and seminal plasma during clomiphene therapy in hypofertile men

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Abstract

The serum and seminal plasma concentrations of androstenedione, testosterone, dihydrotestosterone and 17β oestradiol were investigated in hypo and oligospermic males during clomiphene citrate administration. A significant increase was demonstrated in the serum testosterone, dihydrosterone and 17β oestradiol values, mainly in the first month of therapy. The steroid increase in the ejaculate was less pronounced. Measuring of 17β oestradiol in serum appears to be a useful parameter for estimating the stimulative effect of clomiphene citrate.

Original languageEnglish
Pages (from-to)159-165
Number of pages7
JournalActa Medica Academiae Scientiarum Hungaricae
Volume35
Issue number2
Publication statusPublished - 1978

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Clomiphene
Semen
Estradiol
Steroids
Testosterone
Serum
Androstenedione
Dihydrotestosterone
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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abstract = "The serum and seminal plasma concentrations of androstenedione, testosterone, dihydrotestosterone and 17β oestradiol were investigated in hypo and oligospermic males during clomiphene citrate administration. A significant increase was demonstrated in the serum testosterone, dihydrosterone and 17β oestradiol values, mainly in the first month of therapy. The steroid increase in the ejaculate was less pronounced. Measuring of 17β oestradiol in serum appears to be a useful parameter for estimating the stimulative effect of clomiphene citrate.",
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AB - The serum and seminal plasma concentrations of androstenedione, testosterone, dihydrotestosterone and 17β oestradiol were investigated in hypo and oligospermic males during clomiphene citrate administration. A significant increase was demonstrated in the serum testosterone, dihydrosterone and 17β oestradiol values, mainly in the first month of therapy. The steroid increase in the ejaculate was less pronounced. Measuring of 17β oestradiol in serum appears to be a useful parameter for estimating the stimulative effect of clomiphene citrate.

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