Sterile wounding is a minimal and sufficient trigger for a cellular immune response in Drosophila melanogaster

Róbert Márkus, E. Kurucz, Florentina Rus, I. Andó

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

An attack and oviposition by parasitic wasp Leptopilina boulardi induces a vigorous cellular immune response in Drosophila melanogaster larvae. This response is manifested by the appearance of a specialized subset of blood cells, the lamellocytes, which are the key players in the encapsulation and killing of the parasite. The formation of lamellocytes involves the activation of the Toll, the Jun kinase and the JAK/STAT pathways however the minimal requirement for initiation of lamellocyte development in the course of the cellular immune response has not been defined yet. In this study, we tested whether or not the mechanical injury itself, caused by oviposition, could provide a sufficient signal for lamellocyte development. We found that sterile wounding, comparable to that occurring during oviposition, induces normal lamellocyte development. We propose therefore that mechanical damage of the cuticle and subsequent disruption of the basal lamina is a minimal and sufficient single signal for normal lamellocyte development in the course of the cellular immune response of Drosophila.

Original languageEnglish
Pages (from-to)108-111
Number of pages4
JournalImmunology Letters
Volume101
Issue number1
DOIs
Publication statusPublished - Oct 15 2005

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Oviposition
Drosophila melanogaster
Cellular Immunity
Janus Kinases
Wasps
Basement Membrane
Drosophila
Larva
Blood Cells
Parasites
Wounds and Injuries

Keywords

  • Drosophila
  • Hemocyte differentiation
  • Induction
  • Lamellocyte

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Sterile wounding is a minimal and sufficient trigger for a cellular immune response in Drosophila melanogaster. / Márkus, Róbert; Kurucz, E.; Rus, Florentina; Andó, I.

In: Immunology Letters, Vol. 101, No. 1, 15.10.2005, p. 108-111.

Research output: Contribution to journalArticle

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