Stereospecific conversion of H-phosphonates into phosphoramidates. The use of vicinal carbon-phosphorus couplings for configurational determination of phosphorus

István Tömösközi, E. Gács-Baitz, László Ötvös

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Separated P-diastereomers of H-phosphonate diesters gave exclusively one isomer of amidates on treatment with CCl4 + butylamine with inversion of configuration. NOE experiments and the trend observed in 3J(C2-P) and 3J(C4-P) couplings were applied for stereochemical assignment. Separated P-diastereomers of H-phosphonate diesters gave exclusively one isomer of amidates on treatment with CCl4 + butylamine with inversion of configuration. NOE experiment and the trend observed in 3J(C2-P) and 3J(C4-P) couplings were applied for stereochemical assignment.

Original languageEnglish
Pages (from-to)6797-6804
Number of pages8
JournalTetrahedron
Volume51
Issue number24
DOIs
Publication statusPublished - Jun 12 1995

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Butylamines
Organophosphonates
Isomers
Phosphorus
Carbon
Experiments
phosphoramidic acid

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Stereospecific conversion of H-phosphonates into phosphoramidates. The use of vicinal carbon-phosphorus couplings for configurational determination of phosphorus. / Tömösközi, István; Gács-Baitz, E.; Ötvös, László.

In: Tetrahedron, Vol. 51, No. 24, 12.06.1995, p. 6797-6804.

Research output: Contribution to journalArticle

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